Singapore Age-Related Macular Degeneration Therapeutics Market Analysis

Singapore Age-Related Macular Degeneration Therapeutics Market Analysis


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The Singapore Age-Related Macular Degeneration (AMD) Therapeutics Market was valued at US $13 Mn in 2022, and is predicted to grow at (CAGR) of 9.50% from 2023 to 2030, to US $27 Mn by 2030. The key drivers of this industry include the upward trend in the prevalence of age-related macular degeneration, supportive government initiatives, and other factors. The industry is primarily dominated by players such as Roche, Regeneron Pharmaceuticals, Novartis, Bayer, and Genetech, among others

ID: IN10SGPH427 CATEGORY: Pharmaceuticals GEOGRAPHY: Singapore AUTHOR: Riddhi Solanki

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Singapore Age-Related Macular Degeneration Therapeutics Market Analysis: Executive Summary

The Singapore Age-Related Macular Degeneration (AMD) Therapeutics Market is at around US $13 Mn in 2022 and is projected to reach US $27 Mn in 2030, exhibiting a CAGR of 9.50% during the forecast period.

Age-related macular degeneration (AMD) is a gradual eye condition that mainly affects older individuals, potentially leading to significant loss of vision. It affects the macula, which is responsible for central vision. The non-modifiable risk factors for AMD include diabetes, smoking, lifestyle changes, and other factors. The two major types of AMD are dry AMD and wet AMD, and the common symptoms include distorted vision, difficulty seeing clearly, and a gradual decline in vision. Dry AMD is more common but progresses more slowly, whereas wet AMD, though less prevalent, is more severe and characterized by abnormal blood vessel growth beneath the macula. Treatment options encompass anti-VEGF therapy with medications like Lucentis, Vabysmo, Avastin from Genentech, and Eylea from Regeneron Pharmaceuticals. Additionally, treatment may involve laser therapy and the inclusion of nutritional supplements such as zinc and copper as preventive measures.

It is estimated that the prevalence of AMD is approximately 5% for early AMD and that of late AMD is about 0.5% for people age 50 years and older in Singapore. The market is therefore driven by major factors like an increase in the aging population and the subsequent increase in prevalence, supportive government initiatives, and technological advancements in the therapeutics industry. However, high treatment costs and a lack of local research and development are a few factors that limit the market's potential.

The most notable player in the market is Roche, with its product, Lucentis, capturing a significant portion of the market, followed by Novartis.

Singapore Age-Related Macular Degeneration Therapeutics Market Analysis 2022 to 2030

Market Dynamics

Market Growth Drivers

Surge in the prevalence of AMD: Singapore's aging population is rapidly growing, particularly in the 65+ age group, leading to a rise in the prevalence of AMD, the primary cause of vision loss in the elderly. The estimated prevalence is around 5% for early AMD and about 0.5% for late AMD. Enhanced healthcare and lifestyle improvements contribute to Singaporeans living longer lives, thereby expanding the potential market for AMD treatments.

Technological advancements: Advancements in diagnostic tools, such as optical coherence tomography (OCT), enable the early and accurate detection of AMD, facilitating timely treatment initiation. The field of AMD therapeutics is evolving, with promising developments like gene therapy and extended-duration anti-VEGF medications that may potentially be introduced to the Singapore market in the future.

Government initiatives: Singapore's national healthcare financing programs like MediSave and MediShield offer partial coverage for crucial AMD services such as eye examinations and surgeries, although there are restrictions on costly medications. The government's emphasis on chronic disease management aims to improve efforts to prioritize the management of chronic conditions like AMD, potentially resulting in increased support for research and improved access to treatment.

Market Restraints

High cost of treatments: While effective, the cost of anti-VEGF therapies for wet AMD is remarkably high, surpassing SGD 20,000 per injection. This poses substantial affordability challenges, impacting even individuals with middle incomes and leaving many dependent on the limitations of MediSave coverage.

Unmet medical need: Unlike other countries, Singapore currently lacks approved medications for dry AMD, the more common form. This creates significant unmet demand and hinders the expansion of the market.

Lack of local research and development: Research endeavours focused on AMD therapeutics within the local context are still in their initial phases, resulting in a significant reliance on global advancements for the market.

Notable updates

July 2022, The Singapore Eye Research Institute (SERI) and Roche jointly announced that Vabysmo® (faricimab) has received approval from Singapore's Health Sciences Authority for treating neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME).

Healthcare Policies and Regulatory Landscape

Singapore's healthcare policy and regulatory framework involve various crucial authorities and agencies. The primary entity responsible for overseeing healthcare regulations and licensing in Singapore is the Ministry of Health (MOH). The MOH is entrusted with formulating national health policies, coordinating and advancing medical and healthcare reforms, and supervising the administration of healthcare services in Singapore.

Obtaining a license for healthcare products in Singapore necessitates compliance with the regulations set by the MOH. For pharmaceuticals and medical devices, companies must obtain registration and marketing authorization from the Health Sciences Authority (HSA), which functions as a statutory board under the MOH. This process entails the submission of technical and scientific data to validate the product's safety, quality, and effectiveness.

Competitive Landscape

Key Players

  • F. Hoffman-La-Roche Ltd
  • Novartis AG
  • Regeneron Pharmaceuticals
  • Apellis Pharmaceuticals
  • AbbVie
  • Bayer
  • Pfizer Inc
  • Regenxbio Inc
  • Kanghong Pharma
  • Bausch Health Companies, Inc

1. Executive Summary
1.1 Disease Overview
1.2 Global Scenario
1.3 Country Overview
1.4 Healthcare Scenario in Country
1.5 Patient Journey
1.6 Health Insurance Coverage in Country
1.7 Active Pharmaceutical Ingredient (API)
1.8 Recent Developments in the Country

2. Market Size and Forecasting
2.1 Epidemiology of Disease
2.2 Market Size (With Excel & Methodology)
2.3 Market Segmentation (Check all Segments in Segmentation Section)

3. Market Dynamics
3.1 Market Drivers
3.2 Market Restraints

4. Competitive Landscape
4.1 Major Market Share

4.2 Key Company Profile (Check all Companies in the Summary Section)

4.2.1 Company
4.2.1.1 Overview
4.2.1.2 Product Applications and Services
4.2.1.3 Recent Developments
4.2.1.4 Partnerships Ecosystem
4.2.1.5 Financials (Based on Availability)

5. Reimbursement Scenario
5.1 Reimbursement Regulation
5.2 Reimbursement Process for Diagnosis
5.3 Reimbursement Process for Treatment

6. Methodology and Scope

Singapore Age-Related Macular Degeneration Therapeutics Market Segmentation

By Disease Type

  • Dry AMD
  • Wet AMD

By Drug

  • Lucentis
  • Eylea
  • Beovu

By Age Group

  • Less than 60
  • Between 60-80
  • More than 80

By Stage

  • Early AMD
  • Intermediate AMD
  • Advanced AMD
  • No AMD

By Distribution Channel

  • Hospital Pharmacy
  • Specialty Pharmacy
  • Online Pharmacy

Methodology for Database Creation

Our database offers a comprehensive list of healthcare centers, meticulously curated to provide detailed information on a wide range of specialties and services. It includes top-tier hospitals, clinics, and diagnostic facilities across 30 countries and 24 specialties, ensuring users can find the healthcare services they need.​

Additionally, we provide a comprehensive list of Key Opinion Leaders (KOLs) based on your requirements. Our curated list captures various crucial aspects of the KOLs, offering more than just general information. Whether you're looking to boost brand awareness, drive engagement, or launch a new product, our extensive list of KOLs ensures you have the right experts by your side. Covering 30 countries and 36 specialties, our database guarantees access to the best KOLs in the healthcare industry, supporting strategic decisions and enhancing your initiatives.

How Do We Get It?

Our database is created and maintained through a combination of secondary and primary research methodologies.

1. Secondary Research

With many years of experience in the healthcare field, we have our own rich proprietary data from various past projects. This historical data serves as the foundation for our database. Our continuous process of gathering data involves:

  • Analyzing historical proprietary data collected from multiple projects.
  • Regularly updating our existing data sets with new findings and trends.
  • Ensuring data consistency and accuracy through rigorous validation processes.

With extensive experience in the field, we have developed a proprietary GenAI-based technology that is uniquely tailored to our organization. This advanced technology enables us to scan a wide array of relevant information sources across the internet. Our data-gathering process includes:

  • Searching through academic conferences, published research, citations, and social media platforms
  • Collecting and compiling diverse data to build a comprehensive and detailed database
  • Continuously updating our database with new information to ensure its relevance and accuracy

2. Primary Research

To complement and validate our secondary data, we engage in primary research through local tie-ups and partnerships. This process involves:

  • Collaborating with local healthcare providers, hospitals, and clinics to gather real-time data.
  • Conducting surveys, interviews, and field studies to collect fresh data directly from the source.
  • Continuously refreshing our database to ensure that the information remains current and reliable.
  • Validating secondary data through cross-referencing with primary data to ensure accuracy and relevance.

Combining Secondary and Primary Research

By integrating both secondary and primary research methodologies, we ensure that our database is comprehensive, accurate, and up-to-date. The combined process involves:

  • Merging historical data from secondary research with real-time data from primary research.
  • Conducting thorough data validation and cleansing to remove inconsistencies and errors.
  • Organizing data into a structured format that is easily accessible and usable for various applications.
  • Continuously monitoring and updating the database to reflect the latest developments and trends in the healthcare field.

Through this meticulous process, we create a final database tailored to each region and domain within the healthcare industry. This approach ensures that our clients receive reliable and relevant data, empowering them to make informed decisions and drive innovation in their respective fields.

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Last updated on: 13 February 2024
Updated by: Dr. Purav Gandhi

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