US Hereditary Angioedema Therapeutic Market


  • Type: Rare Disease Area
  • Published : March 2021
  • Region: North America
  • Country: US
  • Report ID : 413

  • Format: PPT, PDF

US Hereditary Angioedema Drug Market – Size, Share, Impact, Growth, Trends, And Forecasts (2019 – 2028)


Report Overview

The US Hereditary angioedema drugs market size stood at USD 1.5 billion in 2019 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period

The US hereditary angioedema therapeutic market size was valued at USD 1.5 billion in 2018. Growing cases of hereditary angioedema (HAE) globally is a key market driver. According to the National Organization for Rare Disorders (NORD), about 1-9 people per 100,000 population are affected by the condition. The actual number of individuals with the condition are significantly higher due to under-reporting and misdiagnosis

Lack of awareness about HAE is a major reason for misdiagnosis, which in turn, leads to inadequate treatment being provided to patients. Most patients with hereditary angioedema are misdiagnosed for conditions related to appendicitis, gastrointestinal disorders, and other non-allergic angioedema. Significant number of patients being misdiagnosed for the condition has generated a vast patient pool with substantial medical needs. This is likely to be a key driving factor for the market

Market Drivers

Rising initiatives for improving awareness levels among the general population is another factor contributing to the growth of the market. HAE International (HAE I), an international hereditary angioedema patient organization, along with other patient organizations from across the globe lend their support to HAE day, which is marked on May 16th every year. The aim of the initiative is to facilitate faster diagnosis and provide optimal standards of treatment and care to patients

1. USA Hereditary Angioedema Drugs Market Overview….…………………..…
A. Market Size
2. Market Growth Drivers………………………………………………………………..
A. Rise in Prevalence of Hereditary Angioedema in USA
B. Growing R&D Investments and Reimbursement Policies
3. Major Types of Treatment for Hereditary Angioedema….…………………….
A. On-demand treatment
B. Prophylactic treatment
4. Hereditary Angioedema Drugs Market Segmentation….………………………
A. Drug class
I. C1-esterase inhibitor
II. Kallikrein inhibitor
III. B2 bradykinin receptor antagonist
IV. Monoclonal antibodies
V. Others
B. Distribution Channel
I. Hospital Pharmacies
II. Retail Pharmacies
III. Online Pharmacies
IV. Others
5. Hereditary Angioedema Drugs Market Share……………..……………………
A. Market Analysis, Insights and Forecast – By Revenue
6. Competitive Landscape…………………………….…………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles…………….………………………………………..……………
A. Pfizer Company Product & Services, Strategies & Financials
B. Sanofi Company Product & Services, Strategies & Financials
C. Kezar Life Sciences Inc. Company, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………..……..……
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth………………………………………………………
A. New Trends and Development of Hereditary Angioedema Drugs Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Drug Class:

The market is segmented based on drug class into C1-esterase inhibitor, Kallikrein inhibitor, B2 bradykinin receptor antagonist, and other drugs such as attenuated androgens and tranexamic acid. C1-esterase inhibitor was the largest segment in terms of revenue in 2018. The dominant share of the segment is attributed to use of the products in both on-demand and prophylactic treatment of HAE

By Distribution Channel:

Based on the distribution channel, the market has been segregated into hospitals, retail, online and other pharmacies

Major Players

Key participants include BioCryst Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; Pharming Group N.V.; CSL Limited; Shire Plc; Attune Pharmaceuticals, Inc.; Adverum Biotechnologies, Inc.; and KalVista Pharmaceuticals, Inc.

Key players are entering into distribution agreements in order to increase their market share boost and their presence across different geographies. For instance, in September 2017, Pharming Group N.V. appointed Inceptua Medicines Access as its distribution partner for HAEi Global Access Program. The move was aimed at helping patients in geographies where Ruconest is not commercially available to gain access to the product through regulatory compliant and ethical mechanisms

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain the high level of accuracy and consistency. The market data is analysed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, market share as well as segment-level analysis of the specific market. Our report includes precise, to the point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
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  • Trade Publications
  • Online Databases
  • Published Research Reports
  • Whitepapers
  • Press Releases of Key Market Players

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and its impact to the different segments within the market.
Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumptions.
The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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