US Biologics for Rheumatoid Arthritis Treatment

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  • Type: Common Disease Area
  • Published : March 2021
  • Region: North America
  • Country: US
  • Report ID : 1082

  • Format: PPT, PDF

US Biologics for Rheumatoid Arthritis Treatment Market- Size, Trends, and Segmented by Treatment Type (IL-1 & IL-6 monoclonal therapy, B-cell inhibitors, T-cell inhibitors, JAK inhibitors, and TNF inhibitors)- Opportunities, New Innovation, and Forecasts (2019-2028)

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Report Overview

The US Biologic drugs for Rheumatoid Arthritis treatment market size stood at around USD XX billion in 2019 and is projected to reach USD XX billion by 2028, exhibiting a CAGR of  XX% during the forecast period

Biologic drugs have proved highly effective for the treatment of immune-mediated inflammatory diseases such as rheumatoid arthritis (RA). These drugs are often considered cost-effective for well-defined RA patient populations not responding adequately to conventional treatment. While most traditional meds are made from chemicals and have known structures, biologics are more complex. They’re typically made from living materials, like animal, human, and bacteria cells. These products represent cutting-edge research and also enable the latest scientific discoveries. Such discoveries can be translated into novel therapies that provide new treatment options for patients. Moreover, an increased understanding of the genetic and molecular basis of disease has opened up the development of a range of targeted treatments

Market Growth Drivers

The market is majorly driven by growing capital investment from the key market players, the rise in the burden of chronic diseases, loss of patent exclusivity of the leading biologic drugs, and growing demand and higher acceptability for innovative therapies

With the growing COVID-19 burden, there is a huge demand for biologics during the pandemic, which might drive market growth. Tobacco use, physical inactivity, alcohol consumption, and unhealthy diets create a risk of dying from non-communicable diseases.​ Also, the rising geriatric population is much susceptible to chronic diseases that help in increasing the biologics demand

Epidemiology

Out of every 100,000 people, 41 are diagnosed with RA every year. About 1.3 million Americans have RA. Women are about two to three times more likely to get RA than men. Hormones in both genders may play a role in either preventing or triggering it. Rheumatoid Arthritis generally starts between the ages of 30 and 60 in women and somewhat later in life in men. The lifetime risk of developing RA is 3.6% for women and 1.97% for men

 

1. US Biologics for Rheumatoid Arthritis Treatment Market Overview………..
A. Market Size
2. Market Growth Drivers……………………………………………………………………..……………….
A. Growing capital investment from the key market players
B. Growing demand and higher acceptability for innovative therapies
3. Epidemiology…………………………………………..………………………………………………………….
A. New Prevalent Cases of Rheumatoid Arthritis
B. Treated cases of Rheumatoid Arthritis with Biologic drugs
4. Biologics for Rheumatoid Arthritis Treatment Market Segmentation………
A. By Treatment Type
I. IL-1 & IL-6 monoclonal therapy
II. B-cell inhibitors
III. T-cell inhibitors
IV. JAK inhibitors
V. TNF inhibitors
5. Biologics for Rheumatoid Arthritis Major Drugs Market Share……………………
A. Market Analysis, Insights and Forecast to 2028 by Revenue
6. Competitive Landscape………………………………………………………….…………………..……..
A. Major Players
B. Products in Pipeline
7. Key Company Profiles…………………………………………………………………………………..…….
A. Roche Company overview, Product & Services, Strategies & Financials
B. Pfizer Inc. Company overview, Product & Services, Strategies & Financials
C. Novartis Company Profile, Product & Services, Strategies & Financials
8. Potential Growth Opportunities……………………………….…………………………..…………
A. Advancements in drug development
B. Untapped markets in developing economies
9. Factors Driving Future Growth…………………………………………………………..
A. Key Industry Trends and Recent Developments in Biologics for Rheumatoid Arthritis Treatment
B. Future Opportunities
10. Conclusion

 

Market Segmentation

By Treatment Type

B-cell inhibitors affect B cells, which are white blood cells that carry a protein that can trigger the immune response. The approval of rituximab for the treatment of rheumatoid arthritis has not only expanded the scope of therapies for rheumatologists but has also led the way to a better understanding of the etiology of autoimmune diseases

Interleukin-1 stops the production of an inflammatory chemical our body makes. Anakinra (Kineret — Amgen) has been approved by FDA for the treatment of moderately to severely active rheumatoid arthritis (RA) in adults who have failed one or more DMARDs. Interleukin-6 stops inflammatory chemicals from attaching to cells. Tocilizumab is a biological therapy and can be prescribed for rheumatoid arthritis

JAK inhibitor blocks proteins that trigger the inflammation process. JAK inhibitors belong to a family of medicine called DMARDs (disease-modifying antirheumatic drugs). The JAK inhibitors, baricitinib(Olumiant), tofacitinib(Xeljanz), and upadacitinib(Rinvog), are approved by FDA to treat Rheumatoid Arthritis. More should appear in the next few years if they succeed in clinical trials

T-cell inhibitor blocks communication between T cells, a type of white blood cell. Abatacept is effective in treating the signs and symptoms of rheumatoid arthritis as well as in inhibiting structural damage. The available evidence indicates that Abatacept (Orencia) has the lowest risk of serious side effects

A(TNF) inhibitor blocks a chemical our body makes that drives the inflammation process. Tumor necrosis factor (TNF)-α antagonists, such as infliximab (IFX), etanercept (ETN), adalimumab (ADA), golimumab (GOLI), and certolizumab pegol (CZP) have been widely used for the treatment of RA

Top Players

Biologic drugs are used in the treatment of Rheumatoid Arthritis and have enabled big pharmaceutical companies, like Roche, Novartis, Biogen Idec, Pfizer, Amgen, and Sanofi Pharmaceutical to invest in these products. There are also increasing investments that have helped in driving the overall market growth. Furthermore, increasing demand for biologics proves efficient in treating rheumatoid arthritis and Crohn’s disease boosting the market

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain the high level of accuracy and consistency. The market data is analysed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, market share as well as segment-level analysis of the specific market. Our report includes precise, to the point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
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  • Press Releases of Key Market Players

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumptions.
The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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