UK Wilson’s Disease Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2600

  • Format: PPT, PDF

UK Wilson Disease Therapeutics Market: Segmented by Diagnosis, Treatment, and Indication – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

SKU: 2600 Categories: ,

Report Overview

The UK Wilson Disease Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

The Wilson disease (WD), also known as hepatolenticular degeneration, and progressive lenticular degeneration, is a rare genetic disorder of copper metabolism characterized by excess copper stored in various body tissues, particularly the liver, brain, and corneas of the eyes. The disease is progressive and if left untreated, may cause liver (hepatic) failure, hemolytic crisis, central nervous system dysfunction, and death. It is caused by a mutation of the ATP7B gene and is inherited in an autosomal recessive manner. Early diagnosis and treatment may prevent serious long-term disability and life-threatening complications. Treatment is aimed at reducing the amount of copper accumulated in the body by chelation therapy and maintaining normal copper levels thereafter.

Wilson disease typically appears in people under 40 years old. Without treatment, life expectancy is estimated to be 40 years, but with prompt and efficient treatment, patients may have a normal lifespan. It is estimated that 1 in 30,000 people are affected by WD in the UK. Approximately one in 90 people may be carriers of the disease gene. Wilson disease is a rare disorder that affects males and females in equal numbers. The disease is found in all races and ethnic groups.

NCARDS is part of Public Health England, which is an executive agency of the Department of Health and Social Care. The Wilson’s Disease Support Group (WDSG-UK), who provide crucial support to WD patients and their families, have been instrumental in spreading the word about NCARDRS to their members and giving us a forum to share our findings with them. We also actively engage with clinicians looking after people with WD, as part of the Wilson’s Disease Special Interest Group (WDSIG).

Market Growth Drivers

The Wilson’s disease Treatment market is primarily driven by the financial incentives and overall rewards for the successful development of drugs for the treatment and diagnosis of rare diseases and conditions. Moreover, the increasing awareness regarding Wilson’s disease by various organizations and associations and its symptoms along with the growing population all over the world is expected to fuel the treatment market. For instance, the Wilson’s Disease Association, a volunteer organization strives to promote the latest information about Wilson’s disease and support research and clinical investigation for the disease.

However, technological advancement in treatment and diagnosis and rising genetic inherited disorders also boost up market growth. Moreover, increasing demand for treatment and rising patient awareness about different treatment options, increasing medical tourism, and rising investment by market players also generate market opportunities.

Market Restraints

However, the high initial investments resulting in higher per-patient treatment cost, adverse effects related to the treatment, and lower treatment rates may hamper the market over the forecast period.


1. UK Wilson Disease Therapeutics Market Overview………………………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Financial Incentives & Overall Rewards for Successful Drugs Development
B. Robust Products Pipeline & Introduction of Novel Therapies
C. Technological Advancements & Rising Genetic Inherited Disorders
Market Restraints
A. Higher per Patient Treatment Cost and Lower Treatment Rates
3. Major Disorders Relatively to Wilson Disease………………………………….
A. Sydenham chorea
B. Primary biliary cholangitis
C. Neuroacanthocytosis
D. Cerebral palsy
E. Tourette syndrome
4. Wilson Disease Therapeutics Market Segmentation……………………………….
A. By Diagnosis
I. Ophthalmic Examination
II. Blood & Urine Tests
III. Liver Tissue Biopsy
IV. Molecular Genetic Testing
V. Haplotype Analysis
VI. DNA Analysis
VII. Others
B. By Treatment
I. Chelating Agents
II. Copper Absorbers
III. Others
C. By Indication
I. Hepatic
II. Neuropsychiatric
III. Ophthalmic
IV. Others (heart and kidney complications)
5. Wilson Disease Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Alexion Company overview, Product & Services, Strategies & Financials
B. Teva Company overview, Product & Services, Strategies & Financials
C. Univar BV Company overview, Product & Services, Strategies & Financials
D. Vivet Company overview, Product & Services, Strategies & Financials
E. Wilson Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Wilson Disease Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, the Wilson disease market can be segmented into

  • ophthalmic examination
  • blood & urine tests
  • liver tissue biopsy
  • molecular genetic testing
  • haplotype analysis
  • DNA analysis
  • Others

Wilson disease can be diagnosed based upon a thorough clinical evaluation, a complete patient history, and specialized tests. Such tests may include slit-lamp examination of the eyes that reveals the presence of Kayser-Fleischer rings; tests of the fluid portion of the blood (serum) that demonstrate low levels of ceruloplasmin, a copper protein; and tests that reveal abnormally high levels of copper excreted in the urine. In some patients, a liver biopsy for copper analysis may be necessary to confirm a diagnosis of Wilson disease. Molecular genetic studies that use DNA from blood cells to search for patterns of differences or similarities, a procedure called haplotype analysis may establish whether a full sibling of an affected patient has Wilson disease, is a carrier of the Wilson disease gene, or is not a carrier. This analysis is available for family members of individuals identified as having Wilson disease. DNA analysis may also be used for diagnosing affected patients. In over half of patients, DNA analysis will reveal mutations that cause Wilson’s disease.

By Treatment:

In terms of treatment, the Wilson disease market can be classified into

  • Chelating Agents
  • Copper Absorbers
  • Others

The chelating agent includes D-Penicillamine, Trientine, Tetrathiomolybdate, and others. Copper absorber agents include zinc acetate and others. Currently, chelating agents are the first line of treatment for achieving symptomatic relief. These medicines deplete the excessive copper levels from the body. However, the side-effects associated with chelating agents are severe such as bone marrow suppression and kidney complications thus hampering its market growth. Copper absorber agents like, Zinc acetate is recommended as an alternative therapy to chelators. However, its effect is prolonged hence used for maintenance therapy only.

By Indication:

By indication, the Wilson’s Disease Treatment Market is segmented into

  • Hepatic
  • Neuropsychiatric
  • Ophthalmic
  • Others (heart and kidney complications)

The Hepatic indications are diagnosed in Wilson’s disease as the reduced biliary excretion of copper results in an excessive accumulation of copper in the liver. According to a study, an estimated 6-12% of people having acute liver failure are affected by Wilson’s disease. The neuropsychiatric indications are manifested in the later stages of the disease manifestation of persistent neurological problems such as Parkinsonism, tremors, and seizures. Involuntary muscle movements, tremors, clumsy gait, and speech difficulties may improve with treatment for Wilson’s disease. Approximately 90 % of the patients exhibiting neuropsychiatric symptoms show the development of Kayser-Fleischer rings (deposition of copper) in the cornea region of the eyes.

Top Major Players

The Wilson disease treatment market is a highly competitive market and major key players are adopting strategies such as mergers and acquisitions, partnerships, and regional expansion along with the increased focus on R&D to stand out as strong competitors in the market. WTX101 (bis-choline tetrathiomolybdate) is a first-in-class copper-protein-binding agent with a unique mechanism of action, as a novel therapy for Wilson’s Disease. The prominent key players are Alexion Pharmaceuticals Inc, Teva Pharmaceuticals, Wilson Therapeutics AB, Univar BV Ltd, Vivet Therapeutics are among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

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