UK Primary Hyperoxaluria (PH) Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2612

  • Format: PPT, PDF

UK Primary Hyperoxaluria (PH) Therapeutics Market: Segmented by Diagnosis, Drugs, Treatment, and Distribution Channels – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021


SKU: 2612 Categories: ,

Report Overview

The UK Primary Hyperoxaluria Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Primary Hyperoxaluria (PH) is an ultra-orphan disease caused by genetic mutations, which results in the build-up of overproduction and accumulation of oxalate in the body. This results in the deposition of calcium oxalate crystals in the kidneys and urinary tract, resulting in urolithiasis, nephrocalcinosis, and ultimately kidney failure. As a result of systemic oxalosis, multi-organ damage occurs which affects bones, eyes, skin, and the heart.

Affected individuals lack functional levels of a specific enzyme that normally prevents the accumulation of oxalate. In the kidneys, excess oxalate binds with calcium to form a hard compound (calcium oxalate) that is the main component of kidney and urinary stones. Common symptoms include the formation of stones throughout the urinary tract (urolithiasis) and kidneys (nephrolithiasis) and progressively increased levels of calcium in the kidneys (nephrocalcinosis).

There are three main types of PH that are inherited in an autosomal recessive pattern: PH1, PH2, and PH3. PH1 is the most severe primary hyperoxaluria and accounts for approximately 80% of cases. According to a study, primary hyperoxaluria has an estimated prevalence of 1 to 3 cases per 1 million population and an incidence rate of approximately 120,000 live births per year. It accounts for 1-2% of pediatric end-stage kidney disease but higher values are reported in specific populations with a high rate of consanguinity. The UK-based National Renal Rare Disease Registry (RaDaR) suggests there are approximately more than 100 patients across all the hospitals who have hyperoxaluria.

Market Growth Drivers

The increasing prevalence of primary hyperoxaluria disease is one of the major market drivers. However, with rising awareness and increased diagnostic facilities, demand for primary hyperoxaluria drugs is expected to be triggered over the forecast period. High investment in research & development by leading industry participants is expected to open a new growth window for them. With strong research and development initiatives, most of the companies are focusing on innovative and cost-effective drug development

An increase in special designation from the regulatory authority is propelling the growth of the PH market. Huge financial support to the researchers for developing novel interventions is boosting the market growth. The high demand for disease-specific novel treatment can also act as a market driver. The competitive scenario of the market and strategic collaborations may also boost the market position during the forecast period

Market Restraints

The high cost of treatment for primary hyperoxaluria acts as a major restraint for the market growth. Additionally, limited operating revenue opportunities for research and development of targeted therapies by many market players will be considered as a challenging factor for the growth of the PH market.


1. UK Primary Hyperoxaluria Therapeutics Market Overview………………………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Increase in special designation from the regulatory authority
B. Huge Financial support to the researchers for developing novel interventions
C. High demand for disease-specific novel treatment
Market Restraints
A. Higher Cost of Treatment and Lower Treatment Rates
B. Limited operating revenue opportunities by many market players
3. Major Types of Hyperoxaluria……………………………………..
A. Primary hyperoxaluria
B. Secondary hyperoxaluria
4. Primary Hyperoxaluria Therapeutics Market Segmentation…………………..
A. By Diagnosis
I. Blood Test
II. Urine Tests
III. X-ray Examination
IV. CT scanning
V. MRI Technique
VI. Biopsy
VII. Molecular genetic testing
VIII. Others
B. Drugs
I. Oxlumo (lumasiran)
II. Calcium Oxalate Urinary Inhibitors
III. Thiazides
IV. Pyridoxine
C. By Treatment
I. Shock wave lithotripsy
II. Percutaneous nephrolithotomy
III. Ureteroscopy
IV. Combined liver-kidney transplantation
V. Sequential liver-kidney transplantation
VI. Isolated kidney transplant
VII. Isolated liver transplant
D. By Distribution Channels
I. Hospital Pharmacies
II. Retail Pharmacies
III. Online Pharmacies
5. Primary Hyperoxaluria Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Alnylam Company overview, Product & Services, Strategies & Financials
B. Allena Company overview, Product & Services, Strategies & Financials
C. Dicerna Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Primary Hyperoxaluria Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, the primary hyperoxaluria therapeutics market can be classified into

  • Blood Tests
  • Urine Tests
  • X-ray Examination
  • CT scanning
  • MRI Technique
  • Biopsy
  • Molecular genetic testing
  • Others

Investigation for PH includes measuring urine and plasma oxalate levels, ruling out the major causes of high oxalate levels. X-ray examinations can reveal the presence of kidney stones or calcium oxalate deposits in tissue. Computed tomography (CT) scanning, a specialized imaging technique, uses a computer and x-rays to create a film showing cross-sectional images of certain tissue structures such as kidney tissue. MRI can detect the severity of systemic oxalosis by imaging the retina, heart, and bone in greater detail. A biopsy involves the surgical removal and microscopic examination of a piece of affected tissue can also reveal the abnormal accumulation of oxalate. Molecular genetic testing for mutations in the specific genes known to cause PH confirms the diagnosis of PH.

By Drugs:

Based on the drugs, the primary hyperoxaluria therapeutics market can be bifurcated into

  • Oxlumo (lumasiran)
  • Calcium Oxalate Urinary Inhibitors
  • Thiazides
  • Pyridoxine

Oxlumo is a synthetic double-stranded siRNA oligonucleotide; indicated for the treatment of primary hyperoxaluria in all age groups, has been anticipated to attain a higher market share over the forecast period. Calcium Oxalate Urinary Inhibitors, like magnesium and orthophosphates, are most commonly preferred. Additionally, Thiazides used to decrease calcium in the urine and pyridoxine (vitamin B6) is known to reduce the body’s production of oxalate, have been advocated to prevent kidney stones.

By Treatment:

Based on the treatment, the primary hyperoxaluria therapeutics market can be categorized into

  • shock wave lithotripsy
  • percutaneous nephrolithotomy
  • ureteroscopy
  • combined liver-kidney transplantation
  • sequential liver-kidney transplantation
  • isolated kidney transplant
  • isolated liver transplant

Treatment for kidney stones may involve shock wave lithotripsy, percutaneous nephrolithotomy, and ureteroscopy. Combined liver-kidney transplantation is an option whether pre-emptive or after the development of end-stage kidney damage. Depending on the response to other treatments and the disease severity, options may include a combined liver-kidney transplant; a sequential liver-kidney transplant; an isolated kidney transplant, or an isolated liver transplant. Transplantation requires life-long immune suppression and carries significant mortality risk.

By Distribution Channels:

In terms of distribution channel, the primary hyperoxaluria therapeutics market can be classified into

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

In terms of value, the hospital pharmacies accounted for the leading market share in 2020, which is attributable to the fact that the majority of the medications for primary hyperoxaluria treatment are dispensed following by the prescription there and can so only be done by trained medical professionals. Hence, the hospital pharmacies segment is anticipated to enhance the market share over the forecast period.

Top Major Players

The UK’s primary hyperoxaluria therapeutics market is a highly competitive market and major key players are adopting strategies; organic as well as inorganic market strategies. Alnylam Pharmaceuticals’ Oxlumo is a synthetic double-stranded siRNA oligonucleotide; indicated for the treatment of primary hyperoxaluria in all age groups, the novel therapeutic possessing an orphan market exclusivity expiry till Nov 2030, expected to fosters the market growth. The prominent key players prevailing in the UK market are Alnylam Pharmaceuticals, Allena Pharmaceuticals Inc, Dicerna Pharmaceuticals Inc, Intellia Therapeutics Inc, and OxThera AB among others.

Research Methodology

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  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

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