UK Neuromyelitis Optica Spectrum Disorder (NMOSD) Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2576

  • Format: PPT, PDF

UK Neuromyelitis Optica Spectrum Disorder Therapeutics Market: Segmented by Type, Treatment, Route of Administration, Distribution Channels, and End Users – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

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SKU: 2576 Categories: ,

Report Overview

The UK Neuromyelitis Optica Spectrum Disorder (NMOSD) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Neuromyelitis Optica Spectrum Disorder (NMOSD) is previously known as Devic Syndrome, a rare and devastating, autoimmune, inflammatory disorder of the central nervous system (CNS) characterized by severe axonal damage, primarily to the optic nerve and the spinal cord, sudden and unpredictable relapses, also known as attacks. Each relapse results in stepwise accumulation of disability, including blindness, paralysis, bowel and bladder dysfunction, and sometimes leads to premature death. Uncontrolled complement activation triggered by anti-AQP4 autoantibodies is a major underlying mechanism of the disease.

The New England Journal of Medicine (NEJM) published positive data regarding the approval of Soliris by the European Medicines Agency (EMA), as a treatment for patients with NMOSD who are anti-AQP4 antibody-positive. Around 97.9 percent of patients receiving SOLIRIS were relapse-free at 48 weeks compared with 63.2 percent of patients receiving placebo. It has been estimated that NMOSD cases rise up to 430/100,000 of the hospital population. Population-based studies over the past two decades showed that Blacks also have a higher NMOSD prevalence than Whites. A study conducted in the UK reported a prevalence rate of 1.8/100,000 among Blacks. In populations with a higher prevalence, the incidence is also higher.

Market Growth Drivers

The emerging markets and huge investment in research and development are the factors responsible for the growth of the NMOSD market. The emergence of new therapies for the acute phase or prevention of NMOSD creates lucrative opportunities for the market.

The NMOSD market is majorly driven by the rise in the incidence of neuromyelitis optica spectrum disorder. In addition, the emergence of drugs used in the prevention of NMOSD and improvement in healthcare facilities are some of the impacting factors that drive the market growth.

Market Restraints

Nevertheless, less trained expertise or technically skilled professionals coupled with high treatment cost significantly hinder the growth of this market.

TABLE OF CONTENTS

1. UK NMOSD Therapeutics Market Overview………………………………….
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Emerging Markets and High Investment in Research and Development
B. Huge Financial Support to the Researchers for Developing Novel Intervention
C. Rise in Prevalence and Incidence of Neuromyelitis Optica Spectrum Disorder
Market Restraints
A. High Cost of Treatment
B. Lack of Skilled Professionals
3. Major Types of NMOSD………………………………………………………………..
A. Relapsing NMOSD
B. Monophasic NMOSD
4. NMOSD Therapeutics Market Segmentation…………………………………
A. By Type
I. NMOSD with Aquaporin-4 Antibodies
II. NMOSD without Aquaporin-4 Antibodies
B. By Treatment
I. C5 Protein Inhibitor
II. Monoclonal Antibodies
III. Corticosteroids
IV. Immunosuppressants
V. Plasmapheresis
VI. Immunoglobulin
C. By Route of Administration
I. Oral
II. Parenteral
III. Others
D. By Distribution Channels
I. Retail Pharmacies
II. Hospital Pharmacies
III. Online Pharmacies
E. By End Users
I. Hospitals and Clinics
II. Homecare
III. Speciality Centres
IV. Others
5. NMOSD Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Alexion Company overview, Product & Services, Strategies & Financials
B. AstraZeneca Company overview, Product & Services, Strategies & Financials
C. Roche Company overview, Product & Services, Strategies & Financials
D. Medimmune Company overview, Product & Services, Strategies & Financials
E. Veila Company overview, Product & Services, Strategies & Financials
F. Genentech Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of NMOSD Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Type:

Based on type, the NMOSD market is segregated into neuromyelitis optica spectrum disorder with aquaporin-4 antibodies and neuromyelitis optica spectrum disorder without aquaporin-4 antibodies. Adults and children with NMOSD demonstrate that myelin oligodendrocyte glycoprotein antibody (MOG-Ab)- associated with younger patients (particularly children) are frequently in males (and do not demonstrate the strong female preponderance seen in AQP4-Ab NMOSD). MOG-Abs are common in children with ADS with both monophasic and relapsing disease courses.

By Treatment:

On the basis of treatment, the NMOSD treatment market can be divided into

  • C5 Protein Inhibitor
  • Monoclonal antibodies
  • Corticosteroids
  • Immunosuppressants
  • Plasmapheresis
  • Immunoglobulin therapy

The medication section is further categorized into C5 Protein Inhibitor, monoclonal antibodies, corticosteroids, immunosuppressive agents, and others. In the UK, the European Medicines Agency (EMA) approved Soliris (eculizumab) as the first approved medical treatment for NMOSD.

By Route of Administration:

Based on the route of administration, the NMOSD treatment of the market can be segmented into

  • Oral
  • Parenteral
  • Others

The parenteral witnesses the huge market growth potential during the forecast period.  As Soliris admixture is administered by intravenous infusion over 35 minutes in adults and 1 to 4 hours in pediatric patients.

By Distribution Channels:

In terms of distribution channels, the NMOSD treatment market has been bifurcated into

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

The hospital pharmacies segment generated the highest revenue in 2020 and is anticipated to witness growth during the forecast period due to most of the major products are prescription products, which are available in hospital pharmacies.

By End Users:

As per the end-user, the NMOSD treatment market has been segmented into

  • Hospitals
  • Homecare
  • Specialty centers
  • Others

The Walton Centre in Liverpool, and John Radcliffe Hospital at Oxford, currently provide the best NMOSD treatment in the UK. Thus, the hospitals’ segment commands the largest market share in terms of value during the forecast period.

Top Major Players

The major key players operating in UK NMOSD treatment markets are Alexion Pharmaceuticals Inc., Medimmune LLC, AstraZeneca, Hoffmann-La Roche Ltd, Veila Bio and, Genentech Inc. prevailing in the UK market during the forecast period. Eculizumab, Inebilizumab, and Satralizumab are most commonly used for neuromyelitis optica spectrum disorder.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

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The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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