UK Myasthenia Gravis Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2570

  • Format: PPT, PDF

UK Myasthenia Gravis Therapeutics Market: Segmented by Disease Type, Diagnosis, Treatment, Route of Administration, and End-Users – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

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SKU: 2570 Categories: ,

Report Overview

The Myasthenia Gravis (MG) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

The Myasthenia Gravis (MG) is a chronic, progressive, and rare neuromuscular disorder that is characterized by weakness of the head, limb, spinal, eye, and respiratory muscles. In MG, antibodies are produced against the acetylcholine receptor (AchR) that impedes the normal transmission of electrical signals from nerves to muscles. MG is often called the “snowflake disease” affecting about 15 in every 100,000 people in the UK.

Myasthenia Gravis occurs more frequently in females than in males, and although symptoms may appear at any age, its onset usually peaks in men in their 50s or 60s and women during their 20s or 30s. There is no proven cure for myasthenia gravis, however, patients can be treated with medications and surgery for the management of the symptoms. The overall EU myasthenia gravis market was valued at USD 0.67 billion in 2019.

Market Growth Drivers

The rise in incidence rate is one of the major factors driving the demand for myasthenia gravis treatment. Advances in technology, rising acceptance of immunotherapies, approval of promising medications, the emergence of biologics are all driving market expansion.

Awareness programs and initiatives are taken by non-profit organizations in UK such as Duchenne UK, Muscular Dystrophy Association (MDA), and Parent Project Muscular Dystrophy (PPMD) and government support in product research & development is expected to create market opportunities during the forecast period.

Market Restraints

On the downside, the high cost of MG treatment and ignorance of signs and symptoms are likely to continues to hinder market proliferation to a certain extent.

TABLE OF CONTENTS

1. UK Myasthenia Gravis Therapeutics Market Overview……………………….
A. Market Size
2. Market Growth Drivers and Restraints…………………………………….
Market Growth Drivers
A. Rising Prevalence and Incidence of Myasthenia Gravis
B. Advances in Technology and Approval of Promising Medications
C. Awareness Programs and Initiatives Taken by Associations
Market Restraints
A. High cost of Treatment associated with Myasthenia Gravis
3. Major Myasthenia Gravis Types………………………………………….……
A. Generalised Myasthenia Gravis
B. Ocular Myasthenia Gravis
C. Lambert Eaton Myasthenic Syndrome
D. Congenital Myasthenic Syndrome
4. Myasthenia Gravis Therapeutics Market Segmentation…………………………………
A. By Disease Type
I. Congenital Myasthenia Gravis
II. Transient Myasthenia Gravis
III. Ocular Myasthenia Gravis
IV. Generalised Myasthenia Gravis
V. Others
B. By Diagnosis
I. Laboratory-based Tests
II. Electrodiagnostic Testing and Imaging
III. Others
C. By Treatment
I. Cholinesterase Inhibitors
II. Immunosuppressive drugs
III. Plasmapheresis (Plasma Exchange)
IV. Intravenous immunoglobulin (IVIG)
V. Others
D. By Route of Administration
I. Oral
II. Parenteral
III. Others
E. By End Users
I. Academic and Research Organisations
II. Diagnostic Centres
III. Hospital and Clinics
IV. Others
5. Myasthenia Gravis Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Alexion Company overview, Product & Services, Strategies & Financials
B. Astellas Company overview, Product & Services, Strategies & Financials
C. Hoffmann-LA Roche Company, Product & Services, Strategies & Financials
D. Grifols Company, Product & Services, Strategies & Financials
E. Avadel Company, Product & Services, Strategies & Financials
F. Novartis Roche Company, Product & Services, Strategies & Financials
G. Pfizer Company, Product & Services, Strategies & Financials
H. GlaxoSmithKline Company, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Myasthenia Gravis Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Disease Type:

The UK myasthenia gravis market has been segmented into

  • Congenital Myasthenia Gravis
  • Transient Myasthenia Gravis
  • Ocular Myasthenia Gravis
  • Generalized Myasthenia Gravis
  • Others

The generalized myasthenia gravis segment accounts for the dominant share of the market. Generalized myasthenia gravis is the most common type of MG which is characterized by weakness in the arms, legs, and neck, as well as the torso.

By Diagnosis:

Based on the diagnosis, the Myasthenia gravis treatment market is segmented into

  • Laboratory-based test
  • Electrodiagnostic testing and imaging
  • Others

The novel technologies for the diagnosis of Myasthenia gravis have been accounted for the highest market share in 2020, as well as, it has also been anticipated to grow over the forecast period.

By Treatment:

Based on treatment, the Myasthenia gravis treatment market is bifurcated into

  • Cholinesterase inhibitors
  • Immunosuppressive drugs
  • Plasmapheresis
  • Intravenous immunoglobulin
  • Thymectomy (surgery)

Oral medication has the biggest market share among the therapies, and this is projected to continue during the forecast period. This is due to the fact that drugs can significantly suppress the immune system while largely managing the symptoms. Immunotherapies like Soliris (eculizumab), corticosteroids, and immunosuppressive medicines like Prograf (tacrolimus) are among the medications used. The use of monoclonal antibodies and immunosuppressants is becoming more common.

Surgery, the other major therapeutic option, is the most invasive and usually involves a thymectomy (thymus removal). Although the thymus deteriorates with age (thymic involution), the full absence of the thymus will drastically decrease the immune system of a patient.

By Route of Administration:

According to the route of administration, the Myasthenia gravis treatment market is segregated into

  • Oral
  • Parenteral
  • Others

Out of these, the oral route is the most preferred one because of ease of use and convenience following which inhalations are preferred & surgery remains the last resort.

By End Users:

As per the end-user, the Myasthenia gravis treatment market has been segmented into

  • Academic and research organizations
  • Diagnostic centers
  • Hospitals and clinics

The hospitals and clinics segment commands the largest market share in terms of value during the forecast period.

Top Major Players

Some of the major prominent players operating in this space include Alexion Pharmaceutical Inc., Astellas Pharma Ltd., Grifols SA, Avadel Pharmaceuticals Plc. Novartis AG, Pfizer, Inc., AbbVie Inc., F. Hoffmann-La Roche Ltd., GlaxoSmithKline Plc, etc. Alexion Pharmaceuticals and Astellas Pharma hold the largest market shares due to the strong sales of their flagship products including Soliris and Prograf. Soliris (eculizumab), a drug developed by Alexion Pharmaceuticals, was recently approved by the MHRA for the treatment of adult patients with generalized myasthenia gravis who are anti-AchR antibody-positive. For this disease, Soliris is the first and only complement inhibitor to be approved.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

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Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
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Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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