UK Hunter Syndrome (Mucopolysaccharidosis II: MPS-II) Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2582

  • Format: PPT, PDF

UK Hunter Syndrome Therapeutics Market: Segmented by Therapeutics, Route of Administration, Distribution Channels, and End Users – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

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SKU: 2582 Categories: ,

Report Overview

The UK Hunter Syndrome Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Hunter syndrome, also known as mucopolysaccharidosis type II (MPS II), is a rare genetic disorder caused by an iduronate-2-sulfatase enzyme deficiency. MPS II is a rare lysosomal inborn error of metabolism that affects every organ of the body. In some people, the brain may be affected in combination with physical symptoms, such as hearing problems, bone, and joint malformation, and heart and breathing difficulties. Their bodies can’t break down a kind of sugar that builds bones, skin, tendons, and other tissue.

The MPS II is an X-linked genetic condition that mostly affects males than females. Although the age of onset, disease severity, and the rate of progression of the disease varies significantly, initial symptoms and findings associated with MPS II usually become apparent in children from two to four years of age. A study in the UK indicated an incidence among males around one in 130,000 male live births. The Hunter syndrome belongs to a larger group of about 50 inherited disorders collectively known as lysosomal storage disorders.

Market Growth Drivers

The introduction of novel therapies, robust product pipeline, rising government initiatives for creating awareness regarding the Hunter syndrome diagnosis and its treatment, and its available therapeutic options are expected to significantly fuel the market growth over the forecast period.

An increase in the number of patients suffering from mucopolysaccharidosis II is likely to fuel the market growth during the forecast period. In addition, rise in healthcare expenses and government initiatives for the betterment of health. Increased R&D activities to counter Hunter syndrome in children are more likely to propel the market demand during the forecast period.

Market Restraints

Increasing collaboration and technological advancements are projected to bring new growth avenues for market players during the forecast period. While the high cost of approved therapeutics and lower treatment rates hampers the market.

TABLE OF CONTENTS

1. UK Hunter Syndrome Therapeutics Market Overview………………………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Rising Government Initiatives and Increased R&D Activities
B. Rise in Prevalence and Incidence of Hunter Disease
Market Restraints
A. High Cost of Approved Therapeutics
B. Lower Treatment Rates
3. Major Treatments of Hunter Syndrome……………………………………..
A. Oral Drugs
B. Therapies
C. Others
4. Hunter Syndrome Therapeutics Market Segmentation……………………………….
A. By Therapeutics
I. Enzyme Replacement Therapy (ERP)
II. Hematopoietic Stem Cell Transplant (HSCT)
III. Gene Therapy
IV. Bone Marrow Transplant
V. Tonsillectomy (Surgery)
VI. Others
B. By Route of Administration
I. Intravenous
II. Intracerebroventicular (ICV)
III. Intrathecal
IV. Others
C. By Distribution Channels
I. Retail Pharmacies
II. Hospital Pharmacies
III. Online Pharmacies
D. By End Users
I. Hospitals and Clinics
II. Homecare
III. Speciality Centres
IV. Others
5. Hunter Syndrome Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Takeda Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Hunter Syndrome Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Treatment:

On the basis of treatment, the Hunter syndrome treatment market is segmented into

  • Enzyme Replacement Therapy (ERT)
  • Hematopoietic Stem Cell Transplant (HSCT)
  • Gene therapy
  • Bone marrow transplant
  • Tonsillectomy (surgery)
  • Others

Out of the available therapies, Enzyme Replacement Therapy is estimated to witness notable growth during the forecast period. ERT consists of replacing the deficient or absent enzyme with a functional recombinant version through intravenous administration. In addition, sales have been significantly increased of several products like Shire Plc’s Elaprase (idursulfase) is one of the major key drug candidates which results in promoting the ERT segment growth during the forecast period.

By Route of Administration:

Based on route of administration, the Hunter syndrome treatment of market can be segmented into

  • Intravenous
  • Intracerebroventricular (ICV)
  • Intrathecal
  • Others

The intravenous type is anticipated to dominate the route of administration segment as Elaprase is administered intravenously. Elaprase holds the monopoly over the Hunter syndrome treatment market and thus, further projected to control its market share during the forecast period.

By Distribution Channels:

In terms of distribution channels, the Hunter disease treatment market has been bifurcated into

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

The hospital pharmacies segment generated the highest revenue in 2020 and is anticipated to witness growth during the forecast period due to most major products are prescription products, which are available in hospital pharmacies.

By End Users:

As per the end-user, the Hunter syndrome treatment market has been segmented into

  • Hospitals
  • Homecare
  • Specialty centers
  • Others

The appropriate and safe administration of critical therapeutics which have to be administered intravenously in hospital settings with trained medical professionals is one of the key reasons for the dominant hospitals’ segment growth during the forecast period.

Top Major Players

The UK Hunter syndrome treatment market is a niche segment and has only a few players in the UK. The prominent players in the market have adopted various strategies to garner maximum market share. Major players operating in the market include Takeda Pharmaceuticals Pvt Ltd (acquired Shire Plc. In 2019). In the UK, ERT is the primary approach and thus, Shire Plc’s Elaprase is only the single major drug approved for the treatment of Hunter syndrome in the UK.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

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The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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