UK Hereditary Angioedema (HAE) Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2578

  • Format: PPT, PDF

UK Hereditary Angioedema Therapeutics Market: Segmented by Drugs-type, Route of Administration, and Distribution Channels – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

SKU: 2578 Categories: ,

Report Overview

The UK Hereditary Angioedema (HAE) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

HAE is a rare inherited disorder characterized by recurrent episodes of the accumulation of fluids outside of the blood vessels, blocking the normal flow of blood or lymphatic fluid and causing rapid swelling of tissues in the hands, feet, limbs, face, intestinal tract, or airway. Usually, this swelling is not accompanied by itching, as it might be with an allergic reaction. Swelling of the gastrointestinal tract leads to cramping. Swelling of the airway may lead to obstruction, a potentially very serious complication.

The symptoms develop as the result of a deficiency or improper functioning of certain proteins that help to maintain the normal flow of fluids through very small blood vessels (capillaries). In some cases, fluid may accumulate in other internal organs. The severity of the disease varies greatly among affected individuals.

Hereditary angioedema is a rare disorder that affects males and females in equal numbers. Symptoms typically begin in early childhood. According to the report, HAE affects between 1/10,000 to 1/50,000 of the population in the UK.

Market Growth Drivers

Intense R&D initiatives by the manufacturers to treat the condition, increasing prevalence of hereditary angioedema and the presence of promising drug pipelines are some more growth factors.

Furthermore, increasing funding for rare genetic diseases and orphan drugs by the government and private companies is also enhancing the interest of the pharmaceutical companies to develop drugs for hereditary angioedema and is fuelling the market growth.

For instance, Recently Takeda Pharmaceutical entered into an agreement for public funding of Takhzyro (lanadelumab), its treatment for eligible HAE patients.

Market Restraints

However, the high cost of treatment and the lack of awareness about HAE is a major reason for misdiagnosis, which in turn, leads to inadequate treatment being provided to patients, which proposes a big challenge for HAE treatment market growth.


1. UK Hereditary Angioedema Therapeutics Market Overview………………………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Presence of robust products pipeline
B. Intense R&D activities by the manufacturers
C. Rising incidence and prevalence of Hereditary angioedema
D. Increasing funding for orphan drugs by government and private companies
Market Restraints
A. Higher Cost of Treatment of Hereditary Angioedema
B. Misdiagnosis leads to inadequate treatment being provided to patients
3. Major Types of Hereditary Angioedema……………………………………………..
A. Type 1 Hereditary Angioedema
B. Type 2 Hereditary Angioedema
C. Type 3 Hereditary Angioedema
4. Hereditary Angioedema Therapeutics Market Segmentation…………………..
A. By Drugs Type
I. C1-esterase inhibitor
II. Kallikrein inhibitor
III. B2 bradykinin receptor antagonists
IV. Attenuated androgens
V. Tranexamic acid
VI. Others
B. By Route of Administration
I. Oral
II. Intravenous (IV)
III. Subcutaneous (SC)
IV. Others
C. By Distribution Channels
I. Hospital Pharmacies
II. Retail Pharmacies
III. Online Pharmacies
5. Hereditary Angioedema Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. CSL Behring Company overview, Product & Services, Strategies & Financials
B. Octapharma Company overview, Product & Services, Strategies & Financials
C. BioCryst Company overview, Product & Services, Strategies & Financials
D. Ionis Company overview, Product & Services, Strategies & Financials
E. Shire ViroPharma Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Hereditary Angioedema Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Drugs Type:

On the basis of drugs type, the Hereditary angioedema treatment market can be classified into

  • C1-esterase inhibitor
  • Kallikrein inhibitor
  • B2 bradykinin receptor antagonists
  • Attenuated androgens
  • Tranexamic acid
  • Others

The C1-esterase inhibitor drugs reported being the largest segment in terms of revenue over the past years. The dominant share of the segment is attributed to the use of the products in both on-demand and prophylactic treatment of HAE. Hence this segment is further anticipated to witness high revenue growth during the forecast period.

By Route of Administration:

Based on the route of administration, the Hereditary angioedema treatment market can be bifurcated into

  • Oral
  • Intravenous (IV)
  • Subcutaneous (SC)
  • Others

The intravenous therapies segment dominated the market in terms of revenue over the past years, due to the fact that the existing therapies for the management of HAE are mostly administered intravenously. Intravenously administered therapies have been the mainstay for treating hereditary angioedema patients for a long time.

On the other hand, subcutaneously administered therapies are expected to exhibit the fastest growth rate throughout the forecast period due to advantages such as convenient dosing and superior efficacy as compared to intravenously administered drugs.

By Distribution Channels:

In terms of distribution channel, the Hereditary angioedema treatment market can be classified into

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

In terms of value, the hospital pharmacies accounted for the leading market share in 2020, which is attributable to the fact that the majority of the medications for Hereditary angioedema

treatment are dispensed following by the prescription there and can so only be done by trained medical professionals. Hence, the hospital pharmacies segment is anticipated to enhance the market share over the forecast period.

Top Major Players

The UK Hereditary angioedema treatment market is an intensively growing market and the prominent market players are more focussing on novel interventions to generate the higher market revenue. Some of the major companies which are currently dominating the market are CSL Behring LLC, Shire ViroPharma Incorporated, Ionis Pharmaceuticals Inc, BioCryst Pharmaceuticals Inc, and Octapharma Pharmaceuticals Inc. among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

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The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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