UK Charcot-Marie-Tooth disease (CMT) Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2611

  • Format: PPT, PDF

UK Charcot-Marie-Tooth Disease (CMT) Therapeutics Market: Segmented by Diagnosis, Therapy-type, and Medication & Surgery – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021

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SKU: 2611 Categories: ,

Report Overview

The UK Charcot-Marie-Tooth Disease (CMT) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Charcot-Marie-Tooth disease (CMT) is a group of inherited conditions that damage the peripheral nerves. It’s also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy (PMA). The peripheral nerves are found outside the main central nervous system (brain and spinal cord). They control the muscles and relay sensory information, such as the sense of touch, from the limbs to the brain.

People with CMT may have the symptoms like muscle weakness in their feet, ankles, legs, and hands, an awkward way of walking, highly arched or very flat feet, numbness in the feet, arms, and hands. The symptoms of CMT usually start to appear between the ages of 5 and 15, although they sometimes do not develop until well into middle age or later. CMT is a progressive condition. This means the symptoms slowly get worse, making everyday tasks increasingly difficult.

CMT is caused by an inherited fault in one of the many genes responsible for the development of the peripheral nerves. This fault means the nerves become damaged over time. A child with CMT may have inherited the genetic fault responsible for the condition from 1 or both of their parents. In the UK, it is estimated that approximately 25,000 people have CMT, making it the most common inherited neurological condition.

Market Growth Drivers

The increasing prevalence of Charcot Marie Tooth disease and the technological advancement in disease treatment will assist in encouraging the growth of the market. An increase in genetic disorders, due to a large number of genes causing this disease, an increase in innovations in this field, will also lead to a boost in the market growth.

The increased focus towards targeted therapies, along with the favorable government policies will additionally heighten numerous opportunities that will commence to the germination of the Charcot Marie Tooth disease market over the forecast period.

Market Restraints

However, the high cost of treatment and the lack of awareness of Charcot Marie Tooth disease acts as a major restraint and as well as may hamper the market growth over the forecast period.

TABLE OF CONTENTS

1. UK Charcot-Marie-Tooth Disease Therapeutics Market Overview………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Increasing incidence and prevalence of Charcot Marie Tooth disease
B. Technological advancement and increase in innovative therapies
C. Huge Financial support to the researchers for developing novel interventions
D. Favourable Government policies and numerous growth opportunities
Market Restraints
A. Higher Cost of Treatment
B. Lack of Awareness
3. Major Types of Charcot-Marie-Tooth Disease……………………………………
A. Charcot-Marie-Tooth 1 (CMT 1) Disease
B. Charcot-Marie-Tooth 2 (CMT 2) Disease
4. Charcot-Marie-Tooth Disease Therapeutics Market Segmentation………….
A. By Diagnosis
I. Nerve conduction test
II. Electromyography (EMG)
III. Nerve biopsy
IV. Pre-implantation genetic diagnosis (PGD)
V. Chorionic villus sampling (CVS)
VI. Amniocentesis
VII. Genetic testing
VIII. Others
B. By Therapy Type
I. Physiotherapy
II. Occupational Therapy
III. Orthoses and walking aids
IV. Stem cell therapy
V. Hormones and gene therapy
VI. Others
C. By Medication & Surgery
I. Non-steroidal anti-inflammatory drugs (NSAIDs)
II. Tricyclic antidepressants (TCAs)
III. Anticonvulsants
IV. Osteotomy
V. Arthrodesis
VI. Plantar fascia release
VII. Spinal surgery
VIII. Others
5. Charcot-Marie-Tooth Disease Major Drugs Market Share……………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Medday Company overview, Product & Services, Strategies & Financials
B. Pharnext Company overview, Product & Services, Strategies & Financials
C. Acceleron Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Charcot-Marie-Tooth Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, the Charcot Marie Tooth disease therapeutics market can be classified into

  • Nerve conduction test
  • Electromyography (EMG)
  • Nerve biopsy
  • Pre-implantation genetic diagnosis (PGD)
  • Chorionic villus sampling (CVS)
  • Amniocentesis
  • Genetic testing
  • Others

A nerve conduction test measures the strength and speed of signals transmitted through your peripheral nerves, the network of nerves that run from the brain and spinal cord to and from the rest of the body, such as the limbs and organs. An unusually slow or weak signal could indicate CMT. Electromyography (EMG) uses a small needle-shaped electrode placed in the skin to measure the electrical activity of your muscles.

Nerve biopsy is a minor surgical procedure where a sample of a peripheral nerve is removed from your leg for testing. PGD involves using in vitro fertilization (IVF), where eggs are removed from a woman’s ovaries before being fertilized with sperm in a laboratory. Chorionic villus sampling (CVS) and Amniocentesis usually carried out during pregnancy to check if a baby will develop CMT. Genetic testing involves taking a blood sample and testing it for defective genes known to cause CMT which can only be confirmed by genetic testing and find out exactly which type of CMT they have.

By Therapy Type:

As per the therapy type, the Charcot Marie Tooth disease therapeutics market can be bifurcated into

  • Physiotherapy
  • Occupational Therapy
  • Orthoses and walking aids
  • Stem cell therapy
  • Hormones and gene therapy
  • Others

Physiotherapy is one of the most important therapies for improving the symptoms of CMT and reducing the risk of muscle contractures, where muscles shorten and lose their normal range of movement. Physiotherapy uses physical methods, such as massage and manipulation, to promote healing and wellbeing. Occupational therapy will be useful if muscle weakness in your arms and hands makes it difficult for you to do day-to-day tasks.

Orthoses are devices worn inside your shoes or on your legs to improve the strength and functionality of your limbs, or to correct your gait (the way you walk). Stem cell therapy, (cells at an early stage of development) are used to repair nerve damage. By using hormones and gene therapy, the progression of the disease can be slowed.

By Medication & Surgery:

Based on the Medication & Surgery, the Charcot Marie Tooth disease therapeutics market can be categorized into

  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Tricyclic antidepressants (TCAs)
  • Anticonvulsants
  • Osteotomy
  • Arthrodesis
  • Plantar fascia release
  • Spinal surgery
  • Others

Joint and muscle pain can usually be controlled by taking non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. While neuropathic pain may be treated with tricyclic antidepressants (TCAs) or anticonvulsant medication. An osteotomy is a surgical procedure used to correct severe flatness of the feet. A cut (incision) is made in the feet to remove or reposition the bones in the feet to correct their shape. After surgery, the feet will need to be kept in plaster for several weeks until the bones have healed.

Arthrodesis involves fusing the 3 main joints in the back of the feet to strengthen the feet, correct their shape and relieve pain. It can be used to correct flat feet and heel deformities, and relieve joint pain. But it may take up to 10 months to fully recover from the operation. Plantar fascia release is a surgical procedure used to relieve persistent heel pain caused by inflamed tendons. During the procedure, part of the tendon is removed and the remaining tendon repositioned and allowed to heal. The abnormal curvature of the spine (scoliosis) can often be treated using a back brace, and by spinal surgery.

Top Major Players

The UK Charcot Marie Tooth disease therapeutics market is a lucrative market and the prominent players are focusing on organic as well as inorganic growth strategies. These activities have paved the way for the expansion of the business and the customer base of market players. Major players operating in the market include Medday Pharmaceuticals Inc, Pharnext SA, and Acceleron Pharma Inc among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

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Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

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We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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