UK Alport Syndrome Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2602

  • Format: PPT, PDF

UK Alport Syndrome Therapeutics Market: Segmented by Diagnosis, Treatment, and End Users – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021


SKU: 2602 Categories: ,

Report Overview

The UK Alport Syndrome Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Alport syndrome is a rare genetic disorder caused by the gene mutation of COL4A3, COL4A4, or COL4A5 & characterized by progressive kidney disease and abnormalities of the inner ear and the eye. Two major types of Alport syndrome are Autosomal Dominant Alport Syndrome (ADAS), and Autosomal Recessive Alport Syndrome (ARAS). The hallmark of the disease is the presence of blood in the urine (haematuria) early in life, with progressive decline in kidney function (kidney insufficiency) that ultimately results in kidney failure, especially in affected males.

Both males and females with ARAS develop kidney failure, often in the teenage years or early adulthood. ADAS tends to be a slowly progressive disorder in which renal insufficiency does not develop until well into adulthood. Individuals with Alport syndrome can also develop progressive hearing loss of varying severity and abnormalities of the eyes that usually do not result in impaired vision.

Alport’s syndrome is not common in the UK. One or two out of 100 people starting dialysis have Alport’s syndrome, with a frequency in the general population of about 1 in 5,000, to 1 in 10,000. The inheritance of Alport’s syndrome nearly applies to 9 out of 10 families. Nearly all the men and about 1 in 10 women with Alport’s syndrome develop kidney failure. Most men develop kidney failure between the ages of 15 and 30, though in some families this is delayed to 50-70 years. About 6 out of 10 women may develop protein in the urine. Although protein in the urine suggests a risk for progression to kidney failure, in many cases the kidney function remains normal and only about 1 in 10 women with Alport’s syndrome ever need dialysis or a kidney transplant.

Market Growth Drivers

Alport syndrome is a major cause of kidney disease among the patient population. The rise in the prevalence of genetic disorders is likely to augment the Alport syndrome market over the forecast period Hence, faster adoption and availability of diagnostic tests across the market are anticipated to augment the Alport syndrome market.

Huge investments by the key players and initiatives by governments for research and development of drugs for managing Alport syndrome and its symptoms are likely to propel the Alport syndrome market. With strong research and development initiatives, most of the companies are focusing on innovative and cost-effective drug development.

Market Restraints

However, the high cost of treatment, less awareness about the syndrome, and its lower treatment rates act as major restraints of the Alport syndrome market.


1. UK Alport Syndrome Therapeutics Market Overview………………………
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Rise in Incidence and Prevalence of Genetic Disorders
B. Faster Adoption and Availability of Wide Range of Diagnostic Tests
C. Strong R&D Initiatives by Governments
Market Restraints
A. Higher Cost of Treatment
B. Lower Treatment Rates
3. Major Types of Alport Syndrome……………………………………
A. Autosomal Dominant Alport Syndrome
B. Autosomal Recessive Alport Syndrome
C. X- linked Alport Syndrome
4. Alport Syndrome Therapeutics Market Segmentation…………………..
A. By Diagnosis
I. Blood Tests
II. Urine Tests
III. Ophthalmic testing
IV. Kidney biopsy
V. Molecular Genetic testing
VI. Others
B. By Treatment
I. ACE Inhibitors
II. Diuretics
III. Statins
IV. Kidney Transplantation
V. Genetic counseling
VI. Surgery
VII. Dialysis
VIII. Others
C. By End Users
I. Hospital
II. Specialty Clinics
III. Medical Research Centres
IV. Home-infusion
V. Others
5. Alport Syndrome Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Regulus Company overview, Product & Services, Strategies & Financials
B. Novartis Company overview, Product & Services, Strategies & Financials
C. Reeta Company overview, Product & Services, Strategies & Financials
D. Mylan Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Alport Syndrome Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, the Alport syndrome treatment market can be classified into

  • Blood Tests
  • Urine Tests
  • Ophthalmic testing
  • Kidney biopsy
  • Molecular Genetic testing
  • Others

Blood and urine tests will be done to check your kidney function and look for traces of blood and protein in your urine. A kidney biopsy (a medical procedure to take small samples of the kidney to look at under the microscope) may also be required to make an accurate diagnosis. Doctors will also check for high-tone deafness. Because Alport syndrome is genetic, it can be helpful to analyze your DNA to look for the gene abnormalities that are known to cause the condition. Demand for molecular genetic testing as an effective diagnostic procedure for Alport syndrome is anticipated to drive the Alport syndrome market over the forecast period.

By Treatment:

Based on the treatment, the Alport syndrome treatment market can be bifurcated into

  • ACE Inhibitors
  • Diuretics
  • Statins
  • Kidney Transplantation
  • Genetic counseling
  • Surgery
  • Dialysis
  • Others

Novel therapeutics like Lademirsen (RG012), a single-stranded chemically modified oligonucleotide, administered by subcutaneous route of administration, and Bardoxolone methyl are the prominent drugs that are used to treat Alport syndrome and anticipated to attain a higher market share over the forecast period.

By End Users;

On the basis of end-users, the Alport Syndrome market is segmented into

  • Hospital
  • Specialty Clinics
  • Medical Research Centres
  • Home-infusion
  • Others

The key factor aiding in the dominance of the hospital segment is the appropriate and safe administration of critical therapeutics used in Alport syndrome treatment by trained medical professionals who can administer only in hospitals with care and proper guidelines. Thus, the potential growth of the hospital segment can be anticipated during the forecast period.

Top Major Players

The UK Alport syndrome treatment market is a lucrative market and various companies are focusing on organic growth strategies such as product launches, product approvals, and others such as patents and events. Additionally, inorganic growth strategies activities witnessed in the market were acquisitions and partnership & collaborations. Major players operating in the market include Regulus Therapeutics Inc, Reeta Pharmaceuticals Inc, Novartis, Mylan Pharmaceuticals UK Limited among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

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The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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