UK Adrenoleukodystrophy (ALD) Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Europe
  • Country: UK
  • Report ID : 2593

  • Format: PPT, PDF

UK Adrenoleukodystrophy (ALD) Therapeutics Market: Segmented by Diagnosis, Therapeutics, Disease Indication, and Distribution Channels – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028)

Published Date: June 2021


SKU: 2593 Categories: ,

Report Overview

The UK Adrenoleukodystrophy (ALD) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Adrenoleukodystrophy (ALD) is a rare, genetic, X-linked metabolic disorder caused by mutations in the ABCD1 gene that result in a deficiency in a peroxisomal protein called adrenoleukodystrophy protein (ALDP). Adrenoleukodystrophy is a result of fatty acid build-up caused by the relevant enzymes not functioning properly, which then causes damage to the myelin sheath of the nerves, resulting in seizures and hyperactivity. Other symptoms include problems with speaking, listening, and understanding verbal instructions.

Adrenoleukodystrophy is a fatal progressive neurogenerative disorder affecting brain white matter. Adrenoleukodystrophy is most commonly observed in childhood and present in both males and females; mainly affects men. The major categories of ALD are childhood cerebral ALD (CCALD), adult cerebral ALD, adrenomyeloneuropathy (AMN), and Addison’s disease. The incidence varying between 0.8 and 4.76 people affected per 100,000 births while the prevalence of ALD is estimated to lie between 1 in 10,000 and 1 in 17,000 individuals.

Market Growth Drivers

The surge in the number of patients is driving the market growth of adrenoleukodystrophy. Rising awareness about adrenoleukodystrophy leads to an increase in potential in research treatment. Moreover, the rise in support and funds for research into new ALD treatments contribute to driving the market growth during the forecast period.

The key industry players are engaged in the development of new products by investment in research & development owing to a rise in the demand for products. This, in turn, is estimated to drive market growth.

Government initiatives to improve healthcare infrastructure leads to an increase the patient access and thereby offers a significant opportunity in the market. Moreover, investment by key players to address the unmet medical needs is providing considerable opportunity in the market which will drive the market growth during the forecast period.

Market Restraints

However, the high cost of treatment of adrenoleukodystrophy disease and side-effects associated with stem cell therapy and corticosteroid replacement therapy is expected to hamper the ALD treatment market growth during the forecast period.


1. UK Adrenoleukodystrophy Therapeutics Market Overview……
A. Market Size
2. Market Growth Drivers and Restraints……….……………………………………….…
Market Growth Drivers
A. Increasing Incidence and Prevalence of Adrenoleukodystrophy
B. Rise in Awareness and Government Initiatives Boosts the Market Growth
C. Development of New Products by Investing in Research & Development
Market Restraints
A. Huge Treatment Costs
B. Drawbacks associated with Novel Therapies
3. Major Types of Adrenoleukodystrophy………………………………………..
A. Childhood Cerebral Adrenoleukodystrophy (CCALD)
B. Adult Cerebral Adrenoleukodystrophy (ACALD)
C. Adrenomyeloneuropathy (AMN)
D. Addison’s Disease
4. Adrenoleukodystrophy Therapeutics Market Segmentation………………….
A. By Diagnostics
I. Blood Test
II. Molecular Genetic Testing
III. Newborn Screening
IV. ACTH Stimulation Test
V. Magnetic Resonance Imaging (MRI)
VI. Others
B. By Therapeutics
I. Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
II. Adrenal Insufficiency Treatment
III. Gene Therapy
IV. Dietary Supplements
V. Others
C. By Disease Indication
I. Childhood Cerebral Adrenoleukodystrophy
II. Adult Cerebral Adrenoleukodystrophy
III. Adrenomyeloneuropathy
IV. Addison’s Disease
D. By Distribution Channels
I. Hospital Pharmacies
II. Retail Pharmacies
III. Online Pharmacies
5. Adrenoleukodystrophy Major Drugs Market Share…………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Bluebird Bio Company overview, Product & Services, Strategies & Financials
B. Minoryx Company overview, Product & Services, Strategies & Financials
C. NeuroVia Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Adrenoleukodystrophy Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

Based on the diagnosis, the Adrenoleukodystrophy therapeutics market can be bifurcated into

  • Blood tests
  • Molecular genetic testing
  • Newborn screening
  • ACTH stimulation test
  • Magnetic resonance imaging (MRI)
  • Others

The blood test used to measure the levels of very long-chain fatty acids in the blood plasma and if these levels are notably high then, physicians will order genetic testing to confirm the diagnosis. Newborn screening is a special type of screening test that newborns receive to see if they have certain diseases. An increase in the concentration of ACTH leads to rising in cortisol in the blood plasma indicated by the ACTH stimulation test. MRI allows physicians to see whether the brain has been damaged, including the loss of myelin in the cerebral white matter.

By Therapeutics:

On the basis of therapeutics, the Adrenoleukodystrophy therapeutics market can be segmented into

  • Allogeneic hematopoietic stem cell transplantation (HSCT)
  • Adrenal insufficiency treatment
  • Gene therapy
  • Dietary therapy
  • Others

In allogeneic hematopoietic stem cell transplantation, affected individuals, receive hematopoietic stem cells from a healthy person, referred to as the donor. The studies showed that HSCT stops the progression of neurological disease in ALD, although it does not improve adrenal insufficiency. In gene therapy, the defective gene present in a patient is replaced with a normal gene to enable the production of the active enzyme and prevent the development and progression of the disease. The novel therapeutics, Lenti-D, Leriglitazone (MIN-102), and Lorenzo’s oil are expected to exhibit strong growth during the forecast period.

By Disease Indication:

By disease indication, the Adrenoleukodystrophy therapeutics market can be segmented into

  • Childhood cerebral ALD (CCALD)
  • Adult cerebral ALD
  • Adrenomyeloneuropathy (AMN)
  • Addison’s disease

By Disease Indication, approximately two-thirds of ALD patients will present with the childhood cerebral form of the disease, which is the most severe form. Therefore, can be expected to gain a higher revenue share during the forecast period.

By Distribution Channels:

In terms of distribution channels, the Adrenoleukodystrophy therapeutics market can be bifurcated into

  • Hospital pharmacies
  • Retail pharmacies
  • Online pharmacies

The hospital pharmacies segment has accounted for the highest market share as the major therapeutics are prescription products. Therefore, hospital pharmacies are further anticipated also to witness growth during the forecast period.

Top Major Players

The UK Adrenoleukodystrophy disorder therapeutics market is highly competitive and provides a great opportunity for market players to account for the maximum market share. The prominent players in the Adrenoleukodystrophy treatment market include Bluebird Bio Inc, Minoryx Therapeutics S.L., NeuroVia Company, Viking Therapeutics, and Aldagen Inc. among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

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The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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