South Korea Hereditary Angioedema (HAE) Therapeutics Market Analysis


  • Type: Rare Disease Area
  • Published : June 2021
  • Region: Asia
  • Country: South Korea
  • Report ID : 4936

  • Format: PPT, PDF

South Korea Hereditary Angioedema (HAE) Therapeutics Market: Segmented By Drug Class (C1 Esterase Inhibitor, Selective Bradykinin B2 Receptor Antagonist, Kallikrein Inhibitor, and others) and By Route Of Administration (Intravenous, Subcutaneous, Oral) – Growth, Trends and Forecasts (2020 – 2028)

SKU: 4936 Categories: ,

Report Overview

The South Korea Hereditary Angioedema (HAE) Therapeutics market size stood at around USD xx billion in 2020 and is projected to reach xx billion by 2028, exhibiting a CAGR of around xx% during the forecast period.

Hereditary angioedema is a disease of congenital deficiency or functional defect in the C1 esterase inhibitor (C1-INH) consequent to mutation in the SERPING1 gene, which encodes C1-INH. This disease manifests as recurrent, non-pitting, non-pruritic subcutaneous, or submucosal oedema as well as an erythematous rash in some cases. These symptoms result from the uncontrolled localized production of bradykinin.

The most commonly affected sites are the extremities, face, gastrointestinal tract, and respiratory system. When the respiratory system is affected by hereditary angioedema, swelling of the airway can restrict breathing and lead to life-threatening obstruction. As per the National Organization for Rare Disorders (NORD), the prevalence of hereditary angioedema is 1 per 50,000 to 1 in 150,000 individuals worldwide. The expected number of patients in Korea is about 1,000. However, as of 2019, only 80 patients were diagnosed with hereditary angioedema in Korea.

Market Drivers

Growing cases of hereditary angioedema (HAE) and rising initiatives for improving awareness levels among the general population are factor contributing to the growth of the market. Pharmaceutical drug manufacturers are increasing focus on developing novel therapeutics for hereditary angioedema in order to cater to the large unmet medical needs. Government initiatives and increase in healthcare spending is also fuelling the HAE therapeutics market. For instance, Takeda Pharmaceutical Korea announced that the Ministry of Health and Welfare would grant expanded reimbursement for its acute hereditary angioedema seizure treatment, Firazyr, from March 2021. The ministry will expand the insurance benefits for Firazyr to two doses per patient from the existing one-dose regimen.

Significant number of patients are being misdiagnosed for the condition, also the number of undiagnosed cases it very high which impedes the market growth.

1. South Korea Hereditary Angioedema (HAE) Therapeutics Market Overview….
A. Market Size
2. Market Growth Drivers……………………………………………….
A. Demand For Innovative Drugs And Novel Technologies
B. Robust Drug Pipelines
C. Increase In Prevalence Of Non-Hodgkin’s Lymphoma
3. Types of Hereditary Angioedema (HAE)…………………………………………
A. Type I HAE
B. Type II HAE
4. Hereditary Angioedema (HAE) Therapeutics Market Segmentation……
A. Drug Class
I. C1 Esterase Inhibitor
II. Selective Bradykinin B2 Receptor Antagonist
III. Kallikrein Inhibitor
IV. others
B. Route Of Administration
I. Intravenous
II. Subcutaneous
III. Oral
5. Hereditary Angioedema (HAE) Therapeutics Market Share…………………
A. Market Analysis, Insights and Forecast – By Revenue
6. Competitive Landscape………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………….
A. Takeda Pharmaceuticals Korea Company Overview, Product & Services, Strategies & Financials
B. Hyupjin Corporation Company Overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth……………………………………
A. New Trends and Development of Hereditary Angioedema (HAE) Therapeutics Market
B. Future Opportunities
10. Conclusion


Market Segmentation

By Drug Class:

According to the drug class, market is segmented into C1 esterase inhibitor, selective bradykinin B2 receptor antagonist, kallikrein inhibitor, and others.

By Route of Administration:

According to route of administration, HAE therapeutics market segments are intravenous, subcutaneous and others.


Top Players

The hereditary angioedema therapeutics market is highly consolidated in terms of competition and consists of limited major players. Some of the companies which are currently dominating the market are Takeda Pharmaceutical Korea, Pharming Healthcare, BioCryst Pharmaceuticals, Sanofi.

Pharming Group N.V.  and their Seoul based South Korean specialty pharma partner Hyupjin have received the marketing authorization for Ruconest in South Korea since 2016. Ruconest was the first approved recombinant C1 esterase inhibitor worldwide.

Launch of Takeda Pharmaceutical Korea’s ‘Firazyr’ has improved the conditions of HAE patients in Korea tremendously. Firazyr is an emergency treatment used for the acute attack of hereditary angioedema over two years of age due to a deficiency of a C1-esterase inhibitor by blocking the vasodilating action of Bradykinin to relieve acute seizures within two hours.

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  9. Reimbursement scenario
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