Global ATTR Market Analysis


  • Type: Rare Disease Area
  • Published : March 2021
  • Region: Worldwide
  • Country: Other
  • Report ID : 282

  • Format: PPT, PDF

Global ATTR Market – Growth, Trends, And Forecasts (2019 – 2028)


Report Overview

The global ATTR drugs market size stood at USD 585 million in 2019 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

ATTR amyloidosis is a rare disease, caused by the build-up of abnormal protein deposits in various tissues of the body. Amyloid deposits cause disorder by damaging the structure and the function of the organs where they are found, and they can affect almost any part of the body. The global ATTR is expected to experience robust growth post the launch of ATTR therapeutic drugs, primarily due to increasing African American population, increasing health care expenditure, and accelerating economic growth. However, the growth of this budding market is hindered by the stringent regulations, high cost of ATTR drugs, misdiagnosis of ATTR disorder and limitation of clinical trials

Market Drivers

The global transthyretin amyloidosis treatment market is likely to be driven by an increase in the prevalence of disease, rise in the population with African origin, increase in awareness, improvement in diagnostic procedures, improving health care services, rapid economic growth in developing countries, and rise in research and development activity. The main driver of the ATTR market expansion will be the approval and launch of the RNA interference therapeutics both ATTR polyneuropathy and ATTR cardiomyopathy. The approval of other pipeline agents of varying mechanism will also drive growth due to the current scarcity of the ATTR market. Another prominent contributor to sales growth the increase in diagnosed prevalence across the 7MM. This increase will be caused by improved understanding and awareness of the disease alongside campaigns by drug developers to increase genetic testing. The key market opportunities lie in addressing unmet needs through the development of efficacious therapies for clearing already deposited amyloid and increasing the number of therapies approved for ATTR cardiomyopathy

1. Global ATTR Market Overview…………………………………..
A. Market Size
2. Market Growth Drivers………………………………………
A. Rise in Global Prevalence of ATTR
B. Growing R&D Investments and Reimbursement Policies
3. Major types of ATTR………………………………………………….
A. Familial Amyloid Polyneuropathy (FAP)
B. Familial Amyloid Cardiomyopathy (FAC)
C. Senile Systemic Amyloidosis (SSA)
4. ATTR Market Segmentation………………………………….
A. Drug Class
I. Amyloid clearance drugs
II. Prothena’s PRX004
III. Proclara’s NPT189
IV. Others
B. Distribution Channel
I. Hospital
II. Clinics
III. Others
C. Geography
I. North America Market Analysis
II. Europe Market Analysis
III. Asia-Pacific Market Analysis
IV. Middle-East and Africa Market Analysis
5. ATTR Major Drugs Market Share……………………………
A. Market Analysis, Insights and Forecast – By Revenue
6. Competitive Landscape…………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles……………………………………………
A. Pfizer Inc., Overview, Product & Services, Strategies & Financials
B. Ionis Pharmaceuticals Inc., Overview, Product & Services, Strategies & Financials
C. Alnylam Pharmaceuticals Inc., Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape…………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth………………………………
A. New Trends and Development of ATTR Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Drug Class:

The ATTR market is expected to start to lean towards use of RNAi therapeutics compared to the oral TTR stabilizers such as Vyndaqel or off-label diflunisal. Onpattro is expected to become a market leader as the drug gains increasing support from KOLs and will pave the way for RNAi therapeutics to lead the market. However, there will be fierce competition as new therapies and mechanisms enter the market such as the amyloid clearance drugs, Prothena’s PRX004 and Proclara’s NPT189, that are in early development stages. These therapies are hoped to meet the huge unmet need of therapy for advanced stage ATTR, which makes up most diagnosed cases

By Disease Indication:

Based on Disease Indication, the ATTR diagnostics market is segmented based on Wild type ATTR amyloidosis and Hereditary ATTR amyloidosis

By Distribution Channel:

Based on distribution channel, the ATTR drugs market has been segmented into hospital pharmacies, clinics, and online pharmacies. The hospital segment dominated the ATTR drugs market, in terms of revenue

By Region:

In terms of region, the global transthyretin amyloidosis treatment market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America leads the transthyretin amyloidosis treatment market due of an increase in the African American population, rise in patient pool, increase in the number of diagnosis procedures, presence of leading manufacturers, and rapid drug development. The market in North America is followed by the market in Europe and Asia Pacific. According to the Amyloidosis Foundation, in the U.S., nearly 4,500 new cases of transthyretin amyloidosis are diagnosed every year. Asia Pacific is anticipated to provide lucrative opportunities to the transthyretin amyloidosis treatment market during the forecast period. Increase in demand for supportive care therapeutics because of an increase in health care expenditure in the region, rise in medical tourism, expansion in the pharmaceutical industry, and high rate of acceptance of new products are expected to drive the global ATTR treatment market

Top 5 Major Players

The global ATTR Market is highly competitive, and the prominent players in the market have adopted various strategies to garner maximum market share. These include collaboration, product launch, partnership, and acquisition. Major players operating in the market include Merck, Pfizer Inc., Ionis Pharmaceuticals Inc., Alnylam Pharmaceuticals Inc., and Prothena Corporation Plc


Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain the high level of accuracy and consistency. The market data is analysed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, market share as well as segment-level analysis of the specific market. Our report includes precise, to the point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
  • Company Websites/Annual Reports
  • Trade Publications
  • Online Databases
  • Published Research Reports
  • Whitepapers
  • Press Releases of Key Market Players

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and its impact to the different segments within the market.
Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumptions.
The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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