China Myasthenia Gravis Therapeutics Market

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: Asia
  • Country: China
  • Report ID : 1570

  • Format: PPT, PDF

China Myasthenia Gravis Therapeutics Market: Segmented by Drug Type (Cholinesterase Inhibitors, Immunosuppressive Drugs), Surgery (Thymectomy), Region (Coastal, Inland)- Size, Growth, Trends, and Forecasts (2019 – 2028)

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Report Overview

The China Myasthenia Gravis Therapeutics market size stood at around USD xx billion in 2019 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of 8.2% during the forecast period.

Myasthenia gravis (MG) is an organ-specific autoimmune disorder of the neuromuscular junction, characterized by specific autoantibodies against skeletal muscular antigens in the postsynaptic membrane. And 85% of all patients experience generalized myasthenia gravis affecting proximal muscles of the extremities and the trunk. The annual incidence of myasthenia gravis in China is 29400 and the prevalence is 165600 in 2019. China has a large number of patients (650,000) who are suffering from MG disease. The admission mortality rate was 14.69%. Most cases of new onset MG occurred in the seventh decade of life. In China, the incidence rate of myasthenic crisis (4.81%) and mortality rate (6.4%) are less as compared to the USA.

Market Drivers

The market is majorly driven by the rising geriatric population (12.57% by end of 2019). The mean age of disease diagnosis was 52.2 years, with adults 55.9 years and children 8.9 years. Key factors that are driving the market growth include rising adoption of immunotherapies, approval of promising drugs, emergence of biologics, increase in incidence (annually in China 29400) and increasing awareness of rare diseases.

However, the side effects caused by several therapeutics are restraining market growth. Some of the products are withdrawn from the market due to serious side effects. In April 2019, high dose combination of Cholinesterase Inhibitors (ChEIs) and Calcineurine Inhibitors (CNIs) such as Mestinon and Prograf are responsible for severe muscle cramps in myasthenia gravis patients. High cost of treatment also impacts the growth of the market.

1. China Myasthenia Gravis Therapeutics Market Overview…………………………….
A. Market Size
2. Market Growth Drivers………………………………………………………………………
A. Increase in Research and Development Activities
B. Increase in Geriatric Population
C. Adaptation of Immunotherapies
D. Approval of Drugs, Emergence of Biologics
E. Increase in Awareness
3. Major Types of Myasthenia Gravis………………………………………………………..
A. Congenital Myasthenia Gravis
B. Transient neonatal Myasthenia Gravis
C. Juvenile Myasthenia Gravis
D. Generalized Myasthenia Gravis
E. Ocular Myasthenia Gravis
4. Myasthenia Gravis Therapeutics Market Segmentation………………………………..
A. By Drug Type
I. Cholinesterase Inhibitors
II. Immunosuppressive Drugs
B. By Surgery
I. Thymectomy
C. By Region
I. Coastal
II. Inland
5. Myasthenia Gravis Major Products Market Share……………………………………..
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………….
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………………
A. Alexion Company Overview, Product & Services, Strategies & Financials
B. Harbour Biomed Company Overview, Product & Services, Strategies & Financials
C. RemeGen Company Overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………….
A. Policy Changes and Reimbursement Scenario
9. Factors Driving Future Growth……………………………………………………………
A. New Trends and Development of Myasthenia Gravis Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Drug Type:

On the basis of drug type, the China Myasthenia Gravis therapeutics market can be segmented into cholinesterase inhibitors and immunosuppressive drugs.

Cholinesterase inhibitors include Pyridostigmine bromide and in China maximum oral dose per day is 480 mg 3 to 4 times. Immunosuppressive drugs consist of such as Glucocorticoids (Prednisone, Methylprednisolone and Dexamethasone), Azathioprine, Cyclosporin A, Tacrolimus (FK-506), Cyclophosphamide, Mycophenolate Mofetil (MMF), Rituximab.

By Surgery:

On the basis of surgery, the China Myasthenia Gravis therapeutics market can be segmented into Thymectomy. Thymectomy is one of the main treatment methods for myasthenia gravis. It is a surgical procedure where the thymus gland is removed to stop the production of autoantibodies that mistakenly attack the muscle-nerve connections in myasthenia gravis patients.

By Region:

On the basis of region, the China Myasthenia Gravis therapeutics market is segmented into coastal and inland regions. The estimated incidence of myasthenia gravis per 100,000 persons-years varied from 0.10 Tibet to 1.17 in Beijing.  The incidence of myasthenia gravis was higher in Coastal areas than that in the Inland areas, especially in circum-Bohai sea zone including Liaoning, Beijing, Hebei, and Shandong provinces. The estimated prevalence of myasthenia gravis is 5.09 in Henan province, 6.47 in Hubei province, and 2.19–11.07 per 100,000 in Guangzhou city.

Fig- Incidence rates of Myasthenia Gravis for 31 provinces and administrative division in mainland China. (According to THE LANCET regional health report published in 2020).

Major Players

Some of key players in the myasthenia gravis therapeutics market are Alexion Pharmaceuticals, Inc.; Harbour BioMed; HanAll Biopharma; Shanghai Zhongxi Sanwei Pharmaceutical Co., Ltd.; Pfizer Inc.; F. Hoffmann-La Roche AG; argenx SE; Zai Lab Limited; RemeGen Co., Ltd; Novartis AG; UCB Pharma;

Many new players are emerging in the myasthenia gravis therapeutics market, as a result of a number of growth opportunities. Key players adopting various strategies such as partnership, licensing agreement. For instance, licensing agreement between HanAll Biopharma-Harbour BioMed’s Batoclimab (HBM9161) receives China CDE breakthrough therapy designation for treatment of adult patients with Myasthenia Gravis. And some universities in China are also developing drugs for MG disease (Sun Yat-Sen University in China is conducting phase III clinical trial of Azathioprine and Leflunomide for treatment of myasthenia gravis).

argenx and Zai Lab announce Strategic Collaboration for Efgartigimod in Greater China. Zai Lab granted exclusive rights to develop and commercialize efgartigimod in Greater China, Efgartigimod is an investigational antibody fragment designed to reduce disease-causing immunoglobulin G (IgG) antibodies and block the IgG recycling process.

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  1. Market overview
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  3. Epidemiology or disease type
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  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

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