Australia Wilson’s Disease Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: APAC
  • Country: Australia
  • Report ID : 4100

  • Format: PPT, PDF

Australian Wilson Disease Therapeutics Market: Segmented by Diagnosis, Treatment, and Indication – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028F)

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Report Overview

The Australian Wilson Disease Therapeutics Market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

The Wilson disease (WD), also known as hepatolenticular degeneration, and progressive lenticular degeneration, is a rare genetic disorder of copper metabolism characterized by excess copper stored in various body tissues, particularly the liver, brain, and corneas of the eyes. The disease is progressive and if left untreated, may cause liver (hepatic) failure, haemolytic crisis, central nervous system dysfunction, and death. It is caused by a mutation of the ATP7B gene and is inherited in an autosomal recessive manner. Early diagnosis and treatment may prevent serious long-term disability and life-threatening complications. Treatment is aimed at reducing the amount of copper accumulated in the body by chelation therapy and maintaining normal copper levels thereafter.

Wilson disease typically appears in people under 40 years old. Without treatment, life expectancy is estimated to be 40 years, but with prompt and efficient treatment, patients may have a normal lifespan. Wilson disease is a rare disorder that affects males and females in equal numbers. The disease is found in all races and ethnic groups.

Market Growth Drivers

The Wilson’s disease Therapeutics market is primarily driven by the financial incentives and overall rewards for the successful development of drugs for the treatment and diagnosis of rare diseases and conditions. Moreover, the increasing awareness regarding Wilson’s disease by various organization and association and its symptoms along with the growing population all over the world is expected to fuel the treatment market.

However, technological advancement in treatment and diagnosis and rising genetic inherited disorders also boost up the market growth. Moreover, increasing demand for treatment and rising patient awareness about different treatment options, increasing medical tourism and rising investment by market players also generate market opportunities.

However, the high initial investments resulting in higher per patient treatment cost, adverse effects related to the treatment and lower treatment rates may hampers the market over the forecast period.

1. Australian Wilson Disease Therapeutics Market Overview……………………
A. Market Size
2. Market Growth Drivers……………………………………….……………………………………………..
A. Financial Incentives & Overall Rewards for Successful Drugs Development
B. Robust Products Pipeline & Introduction of Novel Therapies
C. Technological Advancements & Rising Genetic Inherited Disorders
D. Higher per Patient Treatment Cost
3. Major Disorders Relative to Wilson Disease…………………………………………………..
A. Sydenham chorea
B. Primary biliary cholangitis
C. Neuroacanthocytosis
D. Cerebral palsy
E. Tourette syndrome
4. Wilson Disease Therapeutics Market Segmentation……………………………….
A. By Diagnosis
I. Ophthalmic Examination
II. Blood & Urine Tests
III. Liver Tissue Biopsy
IV. Molecular Genetic Testing
V. Haplotype Analysis
VI. DNA Analysis
VII. Others
B. By Treatment
I. Chelating Agents
II. Copper Absorbers
III. Others
C. By Indication
I. Hepatic
II. Neuropsychiatric
III. Ophthalmic
IV. Others (heart and kidney complications)
5. Wilson Disease Major Drugs Market Share………………………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Alexion Company overview, Product & Services, Strategies & Financials
B. Teva Company overview, Product & Services, Strategies & Financials
C. DRL Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Wilson Disease Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, Wilson Disease Therapeutics market can be segmented into

  • ophthalmic examination
  • blood & urine tests
  • liver tissue biopsy
  • molecular genetic testing
  • haplotype analysis
  • DNA analysis
  • Others

Wilson disease can be diagnosed based upon a thorough clinical evaluation, a complete patient history, and specialized tests. Such tests may include slit-lamp examination of the eyes that reveals the presence of Kayser-Fleischer rings; tests of the fluid portion of the blood (serum) that demonstrate low levels of ceruloplasmin, a copper protein; and tests that reveal abnormally high levels of copper excreted in the urine. In some patients, a liver biopsy for copper analysis may be necessary to confirm a diagnosis of Wilson disease. Molecular genetic studies that use DNA from blood cells to search for patterns of differences or similarities, a procedure called haplotype analysis may establish whether a full sibling of an affected patient has Wilson disease, is a carrier of the Wilson disease gene, or is not a carrier. This analysis is available for family members of individuals identified as having Wilson disease. DNA analysis may also be used for diagnosing affected patients. In over half of patients, DNA analysis will reveal mutations that cause Wilson’s disease.

By Treatment:

In terms of treatment, Wilson Disease Therapeutics market can be classified into

  • Chelating Agents
  • Copper Absorbers
  • Others

Chelating agent includes D-Penicillamine, Trientine, Tetrathiomolybdate and others. Copper absorber agents include zinc acetate and others. Currently, chelating agents are the first line of treatment for achieving symptomatic relief. These medicines deplete the excessive copper levels from the body. However, the side-effects associated with chelating agents are severe such as bone marrow suppression and kidney complications thus hampering its market growth. Copper absorber agents like, Zinc acetate are recommended as an alternative therapy to chelators. However, its effect is prolonged hence used for maintenance therapy only.

By Indication:

By indication, the Wilson’s Disease Therapeutics market is classified into

  • Hepatic
  • Neuropsychiatric
  • Ophthalmic
  • Others (heart and kidney complications)

The Hepatic indications are diagnosed in Wilson’s disease as the reduced biliary excretion of copper results in an excessive accumulation of copper in the liver. According to a study, an estimated 6-12% of people having acute liver failure are affected by Wilson’s disease. The neuropsychiatric indications are manifested in the later stages of the disease manifestation persistent neurological problems such as Parkinsonism, tremors, and seizures. Involuntary muscle movements, tremors, clumsy gait and speech difficulties may improve with treatment for Wilson’s disease. In approximately 90% of the patients exhibiting neuropsychiatric symptoms shows the development of Kayser-Fleischer rings (deposition of copper) in the cornea region of the eyes.

Top Major Players

The Wilson Disease Therapeutics market is a highly competitive market and major key players are adopting strategies such as mergers and acquisitions, partnerships, and regional expansion along with increased focus on R&D to stand out as strong competitors in the market. The prominent key players are Alexion Pharmaceuticals Inc., Teva Pharmaceuticals, Alphapharm Pty Ltd., Dr Reddys Laboratories Australia Pty Ltd., Waymade Australia Pty Limited are among others.

 

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain the high level of accuracy and consistency. The market data is analysed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, market share as well as segment-level analysis of the specific market. Our report includes precise, to the point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
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Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and its impact to the different segments within the market.
Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumptions.
The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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