Australia Pyruvate Kinase Deficiency (PKD) Market Analysis


  • Type: Rare Disease Area
  • Published : April 2021
  • Region: APAC
  • Country: Australia
  • Report ID : 4108

  • Format: PPT, PDF

Australian Pyruvate Kinase Deficiency Therapeutics Market: Segmented by Diagnosis, Treatment, and Distribution Channel – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028F)

SKU: 4108 Categories: ,

Report Overview

The Australia Pyruvate Kinase Deficiency Disease Therapeutics Market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Pyruvate Kinase (PK) Deficiency is an inherited and genetic disorder that affects the red blood cells (RBCs) which is responsible for carrying the oxygen to the body tissue. This condition is also known as Haemolytic Anaemia which is characterized by the broke down of red blood cells prematurely resulting in decreased units of RBCs in body. The complications for the PK can be from mild to severe and sometimes the patient does not show any symptoms. The main cause for PK deficiency is autosomal recessive trait that is the child gets the disease from their family members. The frequency of PKD is not precisely defined, but it has an estimated prevalence of 3 to 8 per 1000000.

Market Growth Drivers

Increase in Pyruvate Kinase (PK) Deficiency in the population and high diagnostic rates are some of the driver factors for the Pyruvate Kinase (PK) Deficiency market growth. Increase in patient population suffering from the genetic disease is also one of the factors for the Pyruvate Kinase (PK) Deficiency market growth.

Market Restraints

Huge financial burden coupled with lack of skilled professionals are the factors that hinder the growth of the Pyruvate Kinase (PK) Deficiency market.

1. Australian Pyruvate Kinase Deficiency Therapeutics Market Overview
A. Market Size
2. Market Growth Drivers and Restraints……………………………………….…
Market Growth Drivers
A. Increase in Disease Burden
B. High Diagnostic Rates
C. Robust Products Pipeline & Introduction of Novel Therapies
D. Technological Advancements
Market Restraints
A. Higher per Patient Treatment Cost
3. Major Disorders Relatively to Pyruvate Kinase Deficiency
A. Acquired Haemolytic Anaemias
B. Congenital Haemolytic Anaemias
4. Pyruvate Kinase Deficiency Therapeutics Market Segmentation……………..
A. By Diagnosis
I. Bilirubin in the blood
II. Complete Blood Count (CBC)
III. Genetic Testing
IV. Haptoglobin Blood Test
V. Osmotic Fragility
VI. Pyruvate Kinase Activity
VII. Stool Urobilinogen
B. By Treatment
I. Blood transfusion
II. Bone marrow transplantation
III. Splenectomy
IV. Phototherapy
V. Folic Acid
VI. Vitamin B
VII. Iron Chelation
VIII. Cholecystectomy
IX. Allogenic hematopoietic Stem Cell Transplantation (HSCT)
C. By Distribution Channel
I. Hospital Pharmacy
II. Retail Pharmacy
III. Online Pharmacy
5. Pyruvate Kinase Deficiency Disease Major Drugs Market Share………………
A. Market Analysis, Insights and Forecast – By Revenue Type
6. Competitive Landscape…………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………….
A. Sanofi-Aventis Company overview, Product & Services, Strategies & Financials
B. Bayer Company overview, Product & Services, Strategies & Financials
C. Mylan Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth…………………………………………………………
A. New Trends and Development of Pyruvate Kinase Deficiency Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Diagnosis:

On the basis of diagnosis, Pyruvate Kinase Deficiency Disease market can be classified into

  • Bilirubin in the blood
  • Complete Blood Count (CBC)
  • Genetic Testing
  • Haptoglobin Blood Test
  • Osmotic Fragility
  • Pyruvate Kinase Activity
  • Stool Urobilinogen

The standard diagnostic test for PKD is to measure the activity of the pyruvate kinase enzyme in red blood cells. Low activity of this enzyme is indictive of the disorder. Molecular genetic testing helps to confirm a diagnosis of PKD. Molecular genetic testing can detect mutations in the PKLR gene known to cause the disorder.

These tests are only run at specialized laboratories; most clinics and hospitals send this test to be run at these specialized centres.

By Treatment:

In terms of treatment, Pyruvate Kinase Deficiency Disease market can be classified into

  • Blood transfusion
  • Bone marrow transplantation
  • Splenectomy
  • Phototherapy
  • Folic Acid
  • Vitamin B
  • Iron Chelation
  • Cholecystectomy
  • Allogenic hematopoietic Stem Cell Transplantation (HSCT)

Treatment may require the coordinated efforts of a team of specialists. Symptoms vary between patients so an individualized treatment plan should be developed. Genetic counselling is recommended for affected individuals and their families. In infants, children, and adults with PKD, blood transfusions may be used. The decision to transfuse is not based on the level of hemoglobin, but, rather, how an individual is tolerating the hemolytic anemia. Sometimes, the surgical removal of the spleen (splenectomy) may be recommended. Removal the spleen may be considered if individuals require frequent blood transfusions or have frequent symptoms from anemia. Supportive care can include gallbladder monitoring due to risk of gallstones. Gallbladder removal (cholecystectomy) is pursued in individuals with symptomatic gallstones and in individuals at the time of splenectomy. Folic acid supplementation, which supports increased red cell production, is often prescribed. Vitamin D, calcium, and exercise may be important for bone health. n allogeneic stem cell transplantation, affected individuals, after treatment with chemotherapy, receive hematopoietic stem cells from a healthy donor. This is a major medical procedure that carries significant risk, including dying from complications related to transplant.

By Distribution of Channel:

On the basis of distribution channel, the Pyruvate Kinase (PK) Deficiency Disease market is segmented into hospital pharmacy, retail pharmacy and online pharmacy.

Top Major Players

The Pyruvate Kinase Deficiency Disease Therapeutics market is less competitive with a smaller number of competitors and major key players are adopting strategies such as mergers and acquisitions, partnerships, and regional expansion along with increased focus on R&D to stand out as strong competitors in the market The prominent key players are Sanofi-Aventis Healthcare Pty Ltd., Teva Pharmaceuticals, Baxter Healthcare Pty Ltd., Bayer Australia Ltd., Mylan Health Pty Ltd. are among others.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

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The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

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