Australia Hypophosphatasia (HPP) Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: APAC
  • Country: Australia
  • Report ID : 4073

  • Format: PPT, PDF

Australian Hypophosphatasia (HPP) Treatment Market: Segmented by Type, Treatment, Route of Administration, Distribution Channel and End Users – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028F)

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Report Overview

The Australian Hypophosphatasia (HPP) Treatment Market size stood at around USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Hypophosphatasia (HPP) is also known as Rathbun disease is an ultra-rare metabolic genetic disorder characterized by the abnormal development of bones and teeth due to defective mineralization, a process by which bones and teeth use minerals such as calcium and phosphorus. It caused by mutations in the tissue nonspecific alkaline phosphatase (TNSALP) gene, also called the ALPL gene. Such mutations lead to low activity of this enzyme that should be breaking down a chemical called inorganic pyrophosphate that blocks mineralization, profound muscle weakness, seizures, respiratory failure and premature death.

Market Drivers

The Hypophosphatasia community are helping to bring programs that will bring new and treatment options to people with rare diseases. Currently, clinical trials are conducted, wherein a large number of organizations are actively participating in several research programs to develop novel therapies for infantile and juvenile-onset hypophosphatasia treatment.

Introduction of several novel therapy, breakthrough therapy designation, orphan drug designation for rare diseases, financial incentives and grants by the government, clinical studies on safety and efficacy of products, is expected to be the biggest hit in the hypophosphatasia market over the forecast period.

Gaps in making Hypophosphatasia (HPP) health priority, patients’ non-adherence to therapy regime, high therapy cost, a smaller number of approved therapies, and failure in clinical trial at the late phase are some of the factors restraining the infantile and juvenile-onset hypophosphatasia treatment market.

1. Australian Hypophosphatasia Treatment Market Overview………………………
A. Market Size
2. Market Growth Drivers…………………………………………………………….……….
A. High Demand of Disease Specific Novel Treatments
B. Huge Financial Support to the Researchers for Developing Novel Intervention
3. Major Clinical Forms of Hypophosphatasia……………………………………………
A. Perinatal Hypophosphatasia
B. Infantile Hypophosphatasia
C. Juvenile Hypophosphatasia
D. Adult Hypophosphatasia
E. Odontohypophosphatasia
4. Hypophosphatasia Treatment Market Segmentation…………………………………..
A. By Type
I. Odonto-hypophosphatasia
II. Pseudo-hypophosphatasia
III. Others
B. By Treatment
I. Asfotase alfa
II. Non-steroidal Anti-inflammatory Drugs
III. Thiazide Diuretics
IV. Surgery
V. Others
C. By Route of Administration
I. Oral
II. Injectables
III. Others
D. By Distribution Channel
I. Retail Pharmacies
II. Hospital Pharmacies
III. Online Pharmacies
IV. Others
E. By End Users
I. Academic and Research Organisations
II. Diagnostic Centres
III. Hospitals and Clinics
5. Australia Hypophosphatasia Major Drugs Market Share…………………………
A. Market Analysis, Insights and Forecast – By Revenue
6. Competitive Landscape………………………………………………………………………
A. Major Players
B. Products in Pipeline
7. Key Company Profiles………………………………………………………………………
A. Alexion Company overview, Product & Services, Strategies & Financials
B. Amgen Australia Pty Ltd Company overview, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………………………….
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth……………………………………………………………
A. New Trends and Development of Hypophosphatasia Treatment market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Type:

Based on type, the Hypophosphatasia Treatment market can be segmented into odonto-hypophosphatasia, pseudo-hypophosphatasia, and others. The odontohypophosphatasia segment accounted for the highest share of the hypophosphatasia treatment market in 2020. This segment is expected to dominate the Hypophosphatasia Treatment market during the forecast period due to high number of patients with odontohypophosphatasia, which is characterized by loss of premature teeth in childhood or loss of teeth in adulthood.

By Treatment:

On the basis of treatment, the Hypophosphatasia Treatment market can be divided into asfotase alfa, non-steroidal anti-inflammatory drugs, thiazide diuretics, surgery and others. The medications generated the highest revenue in 2019 and is anticipated to witness growth during the forecast period. This can be attributed to launch of products for treatment of Hypophosphatasia from major manufacturers. In Australia, Therapeutic Goods Administration (TGA) also approved Strensiq (asfotase alfa) as the first approved medical treatment for infantile, perinatal, and juvenile-onset HPP.

By Route of Administration:

Based on route of administration, the Hypophosphatasia Treatment market can be segmented into oral, injectables and others. The injectables witness huge market growth potential during the forecast period. As asfotase alfa and recombinant human alkaline phosphatase given as an enzyme replacement therapy by the subcutaneous route of administration that targets the underlying cause of the disease.

By Distribution Channel:

In terms of distribution channel, the Hypophosphatasia Treatment market can be divided into hospital pharmacies, retail pharmacies, and online pharmacies. The hospital pharmacies segment generated the highest revenue in 2020 and is anticipated to witness growth during the forecast period due to most of major products are prescription products, which is available in hospital pharmacies. While the COVID-19 pandemic brightens the future of online pharmacies too.

By End Users:

As per the end user, the Hypophosphatasia Treatment market has been segmented into academic and research organizations, diagnostic centres and hospitals and clinics. The hospitals and clinics segment commands the largest market share in terms of value during the forecast period.

Top Major Players

The major key players operating in Australia Hypophosphatasia (HPP) Treatment market are Alexion Pharmaceuticals Inc., and Amgen Australia Pty Ltd primarily. There is currently no permanent solution for Hypophosphatasia. Medical management is aimed at monitoring and alleviating symptoms and decreasing morbidity. Vitamin B6 may also be given to reduce seizures. On the other hand, asfotase alfa by Alexion Pharmaceuticals Inc. and recombinant human alkaline phosphatase by AM-Pharma BV considered as an effective enzyme replacement therapy to treat all forms of hypophosphatasia, prevailing in the market and expected to develop novel therapies for hypophosphatasia treatment during the forecast period.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

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Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

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We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

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Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

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The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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