Australia ATTR Market Analysis

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  • Type: Rare Disease Area
  • Published : April 2021
  • Region: APAC
  • Country: Australia
  • Report ID : 4067

  • Format: PPT, PDF

Australian Transthyretin Amyloidosis (ATTR) Therapeutics Market Segmentation by Drug type, Disease Type, Therapeutics and End User – Size, Share, Impact, Growth, Trends, and Forecasts (2020 – 2028F)

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Report Overview

The Australian Transthyretin Amyloidosis (ATTR) Therapeutics Market size stood at USD xx billion in 2020 and is projected to reach USD xx billion by 2028, exhibiting a CAGR of xx% during the forecast period.

Transthyretin Amyloidosis (ATTR) is a progressive and severe orphan disease. ATTR amyloidosis is a medical disorder marked by the formation of abnormal deposits of a protein called amyloid (amyloidosis) in the organs and tissues of the body. It mostly affects the peripheral neuropathic or autonomic nervous system, as well as the cardiovascular system.

Due to the possibility of additional ATTR therapeutic drugs being introduced, increased healthcare awareness, and growing average income, the market is anticipated to rise significantly during the forecast period.

Market Drivers

The Transthyretin Amyloidosis Therapeutics market is expected to grow rapidly throughout the forecast period, owing to the likelihood of more ATTR therapeutic medicines being launched, more healthcare awareness, and rising average income.

Increasing usage of premium products including Vyndamax, Onpattro, other ATTR stabilizers & Fibril disruptors is among some of the key factors that is expected to drive market growth. Advances in therapeutical approaches and the continuous innovation of therapies are among other factors driving growth. Also, current treatment options are limited, compelling patients to rely on limited therapies.

1. Australian Transthyretin Amyloidosis Drugs Market Overview………..………
A. Market Size
2. Market Growth Drivers…………………………………………………………………..
A. Less Competition in Australian ATTR market
B. Growing R&D Investments
C. Innovative treatment options
3. Major Types of Transthyretin Amyloidosis………………….………..…………….
A. Transthyretin (TTR) Familial Amyloid Cardiomyopathy
B. Transthyretin (TTR) Familial Amyloid Polyneuropathy
4. Transthyretin Amyloidosis Drugs Market Segmentation……………………….
A. Drug Type
I. Diflunisal
II. Tafamidis
III. Patisiran
IV. Doxycycline + Tauroursodeoxycholic acid
V. Inotersen
VI. Others
B. By Disease Type
I. Hereditary type ATTR (HATTR)
II. Wild type ATTR (WT ATTR)
C. By Therapeutics
I. Small Molecules
II. RNAi Therapy
III. Organ Transplantation
IV. Others
D. By End User
I. Hospitals and clinics
II. Ambulatory Surgical Centres
III. Diagnostic Centres
5. Transthyretin Amyloidosis Major Drugs Market Share……………..…………….
A. Market Analysis, Insights and Forecast – By Revenue
6. Competitive Landscape…………………………….………………………………….
A. Major Players
B. Products in Pipeline
7. Key Company Profiles…………….………………………………………..…………..
A. Pfizer Company Product & Services, Strategies & Financials
B. Ionis Pharmaceuticals Product & Services, Strategies & Financials
C. Arcturus Therapeutics, Product & Services, Strategies & Financials
8. Healthcare Policies and Regulatory Landscape……………………..……..……..
A. Policy changes and Reimbursement scenario
9. Factors Driving Future Growth……………………………………………………….
A. New Trends and Development of Transthyretin Amyloidosis Therapeutics Market
B. Future Opportunities
10. Conclusion

Market Segmentation

By Therapeutics:

Transthyretin Amyloidosis can break down into its 127 amino acid monomeric subunits and undergo abnormal modifications, resulting in amyloidogenic intermediates. Transthyretin Amyloidosis is caused by these intermediates self-associating to form amyloid fibrils, which ultimately aggregate as amyloid deposits throughout the body. Various drugs that are used for the treatment of ATTR include Vyndamax (Tafamidis), Vyndaqel (Tafamidis), Dolobid (Diflunsial), Onpattro (Patisiran), Tegsedi (Inotersen).

By Disease Type:

Hereditary (familial) ATTR amyloidosis – This type of ATTR amyloidosis has an alteration (mutation) in the DNA that can be passed down from generation to generation. As a result, the TTR protein becomes more unstable and prone to forming amyloid fibrils. Diverse mutations cause different symptoms: some harm the nerves, others the heart, and still others both.

Wild-type ATTR amyloidosis – Wild-type involves no aberrant DNA and cannot be handed down through the generations. Instead, the normal TTR protein becomes unstable as you get older, misfolds, and creates amyloid fibrils.

By End Users:

By End Users, Transthyretin Amyloidosis Therapeutics market has been segmented into hospitals and clinics, ambulatory surgical centres & diagnostic centres.

Major Players

Some of the key players in the Transthyretin Amyloidosis Therapeutics market are Pfizer Inc; Ionis Pharmaceuticals; Arcturus Therapeutics; Proclara Bioscience; Eidos Therapeutics; Corino Therapeutics Inc.

Key players are adopting various strategies such as mergers & acquisitions to increase their market share. Furthermore, players are collaborating to launch their products in different regions to further strengthen their position in the market.

Research Methodology

Insights10 will provide you reports within 10 key parameters which are:

  1. Market overview
  2. Market growth drivers & restraints
  3. Epidemiology or disease type
  4. Market segmentation
  5. Market share
  6. Competitive landscape
  7. Key company profiles
  8. Healthcare policies & regulatory framework
  9. Reimbursement scenario
  10. Factors driving future growth

Based on our many years of experience, we believe that these are the parameters that are critical to decision making for business stakeholders. Our focused approach to develop reports focused on 10 key parameters, enabled us to arrive at the name “Insights10”.

Our analysis methodology involves three critical stages:

Stage I: Market Data Collection

Primary Interviews: We have developed a network of experts, freelancers and researchers across countries through which we engage with local experts to gather key data points and assumptions around each market. We also engage regularly with some of the best market research agencies such as Atheneum, GuidePoint, GLG, etc. to conduct surveys and interviews, and build intelligence. We have language translators as a part of our team, who between them can cover 30+ languages allowing us to extract better local insights.

Secondary Data Collection: We have developed strong expertise and experience in secondary data collection methods for developing unique data sets and research material. We gather data from multiple reliable sources to maintain the high level of accuracy and consistency. The market data is analysed and forecasted using appropriate statistical and coherent models. The report offers an overall analysis of the market size, growth, market share as well as segment-level analysis of the specific market. Our report includes precise, to the point information related to the overall market, competition, growth drivers, challenges, regulatory updates, and competition.

Data Sources: We have access to multiple highly reliable free and subscription data sources. We have many years of experience to understand which sources are more dependable for what and which to prefer for the reliable and latest information. The key sources of information include the following, but are not limited to:

  • Statistical Databases
  • Company Websites/Annual Reports
  • Trade Publications
  • Online Databases
  • Published Research Reports
  • Whitepapers
  • Press Releases of Key Market Players

Stage II: Market Data Analysis and Statistical Model

Market Trends: We generally look at macro parameter and micro indicators. The macro parameters includes changes in government policies, demand and supply of the market, government intervention programs and major market share. The micro indicators GDP growth, market size, market volume etc. We also understand nuances specific to each country like US, Canada, India, Germany, etc. and have worked across 60+ countries and hence no only understand global trends, but how these differ by country, how payment models, market structure, cultural parameters, etc. differ in each country.

Market Sizing and Analysis: Our expert data analytics team has created various market forecast models by employing the top-down approach i.e. start with large overall market and segment different areas and bottom-up approach i.e. start with population and epidemiology and roll up based on spend, etc., estimating the size of the market, and distributing among the geographic and/or product segments.

The top-down approach mainly used for new product forecasting and bottom-up approach is used for demand estimation of any product for different countries summed up to form total market. We are able to round off insights and build stronger forecasts because we always do both these methods and triangulate the final numbers.

The study on the market covers the analysis of the leading geographies such as North America, Europe, Asia-Pacific, and Africa for the period of 2020 to 2028. The qualitative analysis covers the industry landscape and trends, market opportunities, competitive landscape and policy and regulatory scenario and the quantitative analysis covers different market estimates and forecasts.

Data Triangulation & Validation:

Data triangulation of various sources and results of the research are carried out by benchmarking with reliable sources such as industry statistics, statistical databases and the company level averages etc.

We make sure to finalize the numbers in alignment to the market research. Firstly, our internal experts ensure thorough validation and checking to ensure the accurate and precise analysis and then validation is also done using multiple data analysis model.  Two level validation is done and entails finalization of report scope and to way of representation pattern.

Stage III: Interpretation and Presentation

Analysis & Interpretation: The information gathered is then analysed and synthesized. A second series of interviews are done if necessary to check and validate. The future opportunities are analysed by understanding product commercialization and many other factors. It also comprises the analysis of data discrepancies observed across various data sources. Information procured from secondary and primary results are then, interpreted by considering following parameters: (a partial list)

  • Establishing market drivers and trends
  • Analyzing regulatory landscape to understand future growth
  • Market Segment based analysis to obtain revenue / volume
  • Analyzing current needs and determining penetration to estimate market

Insights: Our reports deliver actionable insights backed with supporting facts and figures to assist you in achieving exemplary growth. Our in-depth analyses are interspersed with relevant insights and statistics to offer an executive-level view of a given market. The description helps in correlating many minor factors affecting the market and its impact to the different segments within the market.
Data curated from the analysis and interpretation are drawn to portray all in one consolidated report.

Presentation & Reporting: The market research report is presented in different forms such as charts by using a scientific approach for easy understanding. Historic, current and future analysis is provided for each market in terms of both value and volume. The size of the market is interpreted in the US Dollar value and the respective unit, based on the product, for volume consumptions.
The foreign exchange rates are calculated on the respective dates and for the respective regions covered in the study.

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